Carinci F, Avantaggiato A, Curioni C
University of Ferrara, Italy.
Cleft Palate Craniofac J. 1994 May;31(3):201-9. doi: 10.1597/1545-1569_1994_031_0201_cscaae_2.3.co_2.
Crouzon syndrome is a craniofaciostenosis characterized by brachycephaly, ocular proptosis, and maxillary retrusion. The hypothesis has been forwarded that an alteration in anterior cranial base synchondrosis activity is responsible for the skeleton abnormalities which are associated with this disorder. The present work was aimed at assessing this pathogenetic hypothesis. Cephalometry was used as the analysis method and care was taken in determining the three-dimensional measurements of some functional spaces (e.g., orbit, rhinopharynx, and nasal cavity). The results indicate that in Crouzon syndrome the craniofacial alterations depend not only on reduced synchondrosis activity of the anterior cranial base, but also of the posterior cranial base.
克鲁宗综合征是一种颅面骨发育狭窄症，其特征为短头畸形、眼球突出和上颌后缩。有人提出假说，认为前颅底软骨结合活动的改变是导致与该疾病相关的骨骼异常的原因。本研究旨在评估这一发病机制假说。采用头影测量法作为分析方法，并在确定一些功能空间（如眼眶、鼻咽和鼻腔）的三维测量值时格外小心。结果表明，在克鲁宗综合征中，颅面改变不仅取决于前颅底软骨结合活动的降低，还取决于后颅底软骨结合活动的降低。
