Bansode F W
Division of Endocrinology, Central Drug Research Institute, Lucknow, India.
Contraception. 1994 Jun;49(6):601-7. doi: 10.1016/0010-7824(94)90101-5.
Female Rhinopoma kinneari, a microchiropteran bat (body weight Ca 15.0 gm to 20.0 gm), was used as a model to evaluate the effect of a single oral dose of 10 mg of gossypol acetate on the ovarian histology at day 2, 4, 6 and 8, respectively. Maximal damage to these organs was seen on day 2. The test drug induced widespread disturbance in the ovarian histoarchitecture as evidenced by an extensive degeneration of follicle types. Degenerative changes were marked by pycnosis, chromatolysis of nuclei, desquamation of granulosa cells and their subsequent dissolution. Intensity of protein staining was increased with time, indicating marked damage to ovarian constituents. It is suggested that gossypol may cause antifolliculogenic activity.
雌性基氏菊头蝠，一种小型食虫蝙蝠（体重约15.0克至20.0克），被用作模型来评估单次口服10毫克醋酸棉酚分别在第2天、第4天、第6天和第8天对卵巢组织学的影响。在第2天观察到对这些器官的最大损伤。受试药物引起卵巢组织结构广泛紊乱，表现为卵泡类型广泛退化。退化性变化的特征为细胞核固缩、核溶解、颗粒细胞脱落及其随后的溶解。蛋白质染色强度随时间增加，表明卵巢成分受到明显损伤。提示棉酚可能具有抗卵泡生成活性。
