Rogoza A, Mierzejewski W, Puzio M
Kliniki Połoznictwa Instytutu Połoznictwa i Chorób Kobiecych Am, Gdańsku.
Ginekol Pol. 1994 Feb;65(2):75-9.
The role of prolactin in males has not been satisfactorily explained. It has been proved that hyperprolactinemia has a negative effect both on spermiogenesis and spermatogenesis. It is widely known that the secretion of the pituitary hormones is of a pulsating character and occurs in the diurnal rhythm. Therefore, in order to select a group of patients with hyperprolactinemia qualified for Bromocriptine treatment it was necessary to test them for prolactin. 3 morning tests were taken at 15 minute intervals. The selected male group was later treated with Bromocriptine, following the method of administration recommended by the producer. Next the level of prolactin in patients serum was again determined. It has been determined that a single prolactin test is sufficient to diagnose hyperprolactinemia. In most males 3 prolactin tests were always either pathologic or normal. Most of the selected hyperprolactinemia--affected males after Bromocriptine treatment displayed positive therapeutic effects. The level of prolactin has dropped considerably and the potency has increased. The improvement in the semen picture varied from patient to patient.
催乳素在男性体内的作用尚未得到令人满意的解释。已证实高催乳素血症对精子发生和生精过程均有负面影响。众所周知，垂体激素的分泌具有脉冲性，且呈昼夜节律。因此，为了挑选出适合用溴隐亭治疗的高催乳素血症患者群体，有必要对他们进行催乳素检测。每隔15分钟进行3次早晨检测。随后，所选男性群体按照生产商推荐的给药方法接受溴隐亭治疗。接着再次测定患者血清中的催乳素水平。已确定单次催乳素检测足以诊断高催乳素血症。在大多数男性中，3次催乳素检测结果要么总是病理性的，要么总是正常的。大多数所选的受高催乳素血症影响的男性在接受溴隐亭治疗后显示出积极的治疗效果。催乳素水平大幅下降，性功能增强。精液情况的改善因患者而异。
