Spurkland A, Knutsen I, Undlien D E, Vartdal F
Institute of Transplantation Immunology, National Hospital, Oslo, Norway.
Hum Immunol. 1994 Apr;39(4):299-301. doi: 10.1016/0198-8859(94)90273-9.
MS is associated with genes in the HLA complex. We have previously proposed that the primary HLA-associated susceptibility may be conferred by particular DQ alleles. Furthermore, we have previously found that there is no association of MS to DP alleles. This study shows that MS is not associated to alleles of the TAP2 locus, which is located close to DQ on its centromeric side. This observation provides further support to the notion that HLA-associated susceptibility to MS maps telomeric to the TAP2 locus.
多发性硬化症与HLA复合体中的基因相关。我们之前曾提出，主要的HLA相关易感性可能由特定的DQ等位基因赋予。此外，我们之前发现多发性硬化症与DP等位基因无关联。本研究表明，多发性硬化症与位于着丝粒侧靠近DQ的TAP2基因座的等位基因无关。这一观察结果进一步支持了以下观点：HLA相关的多发性硬化症易感性定位于TAP2基因座的端粒侧。
