Kato T, Takahashi S, Shioiri T, Murashita J, Hamakawa H, Inubushi T
Department of Psychiatry, Shiga University of Medical Science, Japan.
J Affect Disord. 1994 Jun;31(2):125-33. doi: 10.1016/0165-0327(94)90116-3.
Brain phosphorus metabolism was measured by 31P-MRS in 15 patients with bipolar II disorder (BP II) and 14 patients with bipolar I disorder (BP I). Phosphocreatine (PCr)levels were significantly lower in patients with BP II in all three psychiatric states compared to 59 normal controls (PCr (%) was 13.5 +/- 1.5 (mean +/- SD) for controls, and 12.2 +/- 1.7, 12.1 +/- 1.3, 12.0 +/- 1.9 for hypomanic, euthymic and depressed bipolar II patients respectively). High values of phosphomonoester (PME) were found in BP II patients in the hypomanic and depressive states, but PME values in the euthymic state did not differ significantly from controls. Intracellular pH of BP II patients in all three psychiatric phases was similar to control values, whereas euthymic BP I patients had lower pH values. These results suggest that brain high energy phosphate metabolism may be impaired in BP II and that there may be pathophysiological differences between BP I and BP II.
通过31P磁共振波谱法测量了15例双相II型障碍（BP II）患者和14例双相I型障碍（BP I）患者的脑磷代谢。与59名正常对照相比，BP II患者在所有三种精神状态下的磷酸肌酸（PCr）水平均显著降低（对照组的PCr（%）为13.5±1.5（平均值±标准差），轻躁狂、心境正常和抑郁的BP II患者分别为12.2±1.7、12.1±1.3、12.0±1.9）。在轻躁狂和抑郁状态的BP II患者中发现磷酸单酯（PME）值较高，但心境正常状态下的PME值与对照组无显著差异。BP II患者在所有三个精神阶段的细胞内pH值与对照值相似，而心境正常的BP I患者的pH值较低。这些结果表明，BP II患者的脑高能磷酸代谢可能受损，并且BP I和BP II之间可能存在病理生理学差异。
