Kato T, Takahashi S, Shioiri T, Inubushi T
Department of Psychiatry, Shiga University of Medical Science, Japan.
J Affect Disord. 1992 Dec;26(4):223-30. doi: 10.1016/0165-0327(92)90099-r.
Brain phosphorus metabolism was measured in 22 patients with depressive disorders. Ten of them had DSM-III-R bipolar disorder, and 12 had major depression. In bipolar patients, phosphomonoester (PME) and intracellular pH were significantly increased in the depressive state than in the euthymic state, while those values in the euthymic state were significantly low as compared to age-matched normal controls. Phosphocreatine (PCr) was significantly decreased in severely depressed patients compared to mild depressives. These findings suggest that high energy phosphate metabolism, intracellular pH and membrane phospholipid metabolism are altered in depressive disorders.
对22例抑郁症患者的脑磷代谢进行了测量。其中10例患有DSM-III-R双相情感障碍，12例患有重度抑郁症。在双相情感障碍患者中，与心境正常状态相比，抑郁状态下的磷酸单酯（PME）和细胞内pH值显著升高，而心境正常状态下的这些值与年龄匹配的正常对照组相比显著降低。与轻度抑郁症患者相比，重度抑郁症患者的磷酸肌酸（PCr）显著降低。这些发现表明，抑郁症患者的高能磷酸代谢、细胞内pH值和膜磷脂代谢发生了改变。
