Rubin E M, Smith D J
Department of Cell and Molecular Biology, Lawrence Berkeley Laboratory, University of California, Berkeley 94720.
Trends Genet. 1994 Jun;10(6):199-203. doi: 10.1016/0168-9525(94)90256-9.
The mouse is being increasingly used as a model system for understanding the common and complex polygenic condition of atherosclerosis. Mice have been created in which genes involved in this condition have been overexpressed or have been altered by gene targeting. Here, we concentrate on recent experiments that use transgenic and gene knockout mice as an in vivo assay system to unravel the interactions between various genes involved in atherogenesis. We focus in particular on examples in which unique insights into the human condition have been derived from studies in mice.
小鼠正越来越多地被用作一种模型系统，以了解动脉粥样硬化这种常见且复杂的多基因病症。人们已培育出一些小鼠，其中参与该病症的基因已被过度表达或通过基因靶向技术进行了改变。在此，我们着重介绍最近的一些实验，这些实验使用转基因小鼠和基因敲除小鼠作为体内检测系统，以阐明参与动脉粥样硬化形成的各种基因之间的相互作用。我们特别关注那些从小鼠研究中获得了对人类病症独特见解的例子。
