Shih D M, Welch C, Lusis A J
Department of Medicine, University of California, Los Angeles 90095, USA.
Mol Med Today. 1995 Nov;1(8):364-72. doi: 10.1016/s1357-4310(95)93834-6.
Atherosclerosis is a disease of the large arteries that is the cause of heart disease and stroke. It is a highly complex disorder with multiple genetic and environmental influences. The mouse model has proved very useful for studying atherosclerosis because genetic analysis and planned genetic modification are feasible in this organism. In this brief review, some recent findings are summarized and future prospects using mouse models to study atherosclerosis-related traits are discussed.
动脉粥样硬化是一种发生在大动脉的疾病，是心脏病和中风的病因。它是一种高度复杂的病症，受到多种遗传和环境因素的影响。小鼠模型已被证明在研究动脉粥样硬化方面非常有用，因为在这种生物体中进行遗传分析和有计划的基因改造是可行的。在这篇简短的综述中，总结了一些近期的发现，并讨论了使用小鼠模型研究动脉粥样硬化相关特征的未来前景。
