Monaghan M L, Doherty M L, Collins J D, Kazda J F, Quinn P J
Faculty of Veterinary Medicine, University College Dublin, Ballsbridge, Ireland.
Vet Microbiol. 1994 May;40(1-2):111-24. doi: 10.1016/0378-1135(94)90050-7.
Tuberculin tests in general use today rely on the response to intradermal injections of tuberculin with assessment of the injection site for swelling at 72 hours post injection. Estimates of the sensitivity of tuberculin tests range from 68-95% while specificity is estimated to be 96-99%. The sensitivity of the test is affected by the potency and dose of tuberculin administered, the interval post-infection, desensitisation, deliberate interference, post-partum immunosuppression and observer variation. Specificity is influenced by sensitisation as a result of exposure to M. avium, M. paratuberculosis and environmental mycobacteria and by skin tuberculosis.
如今普遍使用的结核菌素试验依赖于对皮内注射结核菌素的反应，并在注射后72小时评估注射部位是否肿胀。结核菌素试验的敏感性估计范围为68%-95%，而特异性估计为96%-99%。该试验的敏感性受所施用结核菌素的效力和剂量、感染后的间隔时间、脱敏、蓄意干扰、产后免疫抑制以及观察者差异的影响。特异性受因接触鸟分枝杆菌、副结核分枝杆菌和环境分枝杆菌而致敏以及皮肤结核的影响。
