Narasimhachari N, Leiner K, Brown C
Clin Chim Acta. 1975 Jul 23;62(2):245-53. doi: 10.1016/0009-8981(75)90234-x.
Methods for the determination and quantitation of homovanillic, isohomovanillic, 3,4-dihydroxyphenylacetic and 3-methoxy-4-hydroxymandelic acids in single samples of biological material by gas chromatography, gas chromatographic mass spectrometry and selected ion monitoring during gas chromatographic mass spectrometry are described. Examples of the levels of these four acid metabolites of catecholamines in serum and CSF of untreated dog, cat and human, in urine of parkinsonian subjects treated with varying doses of L-DOPA and in CSF of dogs which had received 1 g of L-DOPA per day for 7 weeks are presented.
描述了通过气相色谱法、气相色谱 - 质谱法以及气相色谱 - 质谱法中的选择离子监测来测定和定量生物材料单个样本中高香草酸、异高香草酸、3,4 - 二羟基苯乙酸和3 - 甲氧基 - 4 - 羟基扁桃酸的方法。给出了未经治疗的狗、猫和人类血清及脑脊液中儿茶酚胺这四种酸性代谢物的水平示例，接受不同剂量左旋多巴治疗的帕金森病患者尿液中这四种酸性代谢物的水平示例，以及每天接受1克左旋多巴治疗7周的狗脑脊液中这四种酸性代谢物的水平示例。
