通过气液色谱法和电子捕获检测法对神经组织中3,4-二羟基苯乙酸、高香草酸和高异香草酸进行测定。
The estimation of 3,4-dihydroxyphenylacetic acid, homovanillic acid and homo-isovanillic acid in nervous tissue by gas-liquid chromatography and electron capture detection.
作者信息
Pearson J D, Sharman D F
出版信息
Br J Pharmacol. 1975 Jan;53(1):143-8. doi: 10.1111/j.1476-5381.1975.tb07342.x.
Abstract
1 A gas chromatographic method using electron capture detection is described for the estimation of three acidic metabolites of dopamine, 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid, HVA), 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-hydroxy-4-methoxyphenylacetic acid (homo-isovanillic acid, iso-HVA). The method is based on the formation of the trifluoroacetyl-hexafluoroisopropyl derivatives of the three acids. 2 The method has been applied to the estimation of DOPAC, HVA and iso-HVA in tissues from the central and peripheral nervous systems.
摘要
- 描述了一种使用电子捕获检测的气相色谱法，用于测定多巴胺的三种酸性代谢物，即4-羟基-3-甲氧基苯乙酸（高香草酸，HVA）、3,4-二羟基苯乙酸（DOPAC）和3-羟基-4-甲氧基苯乙酸（高异香草酸，iso-HVA）。该方法基于这三种酸的三氟乙酰-六氟异丙酯衍生物的形成。2. 该方法已应用于中枢和外周神经系统组织中DOPAC、HVA和iso-HVA的测定。
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本文引用的文献
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A discussion of the modes of action of drugs which increase the concentration of 4-hydroxy-3-methoxyphenylacetic acid (homovanillic acid) in the striatum of the mouse.关于能提高小鼠纹状体中4-羟基-3-甲氧基苯乙酸（高香草酸）浓度的药物作用模式的讨论。
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