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酶消化对过敏反应嗜酸性粒细胞趋化因子（EFC-A）活性的影响。

The effect of enzyme digestions on the activity of eosinophil chemotactic factor of anaphylaxis (EFC-A).

作者信息

Bach M K, Jones D G, Kay A B

出版信息

Immunology. 1975 Apr;28(4):773-9.

PMID:807520
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445822/
Abstract

Preparations of ECF-A derived from anaphylactic guinea-pig lung diffusates were subjected to a variety of enzymatic degradations. The enzymes employed had specificityonly for their appropiate subtstates. No effect was found following treatmentwith relatively high doses of trypsin, alpha-chymotrypsin, pronase, alkaline phosphataseand sialidase. In contrast a loss of activity was demonstated in a dose-dependent fashion following incubation with tyrosinase, aryl sulphatase and leucine aminopeptidase, suggesting that ECF-A contains a phenolic hydroxyl group, a sulphate ester anda peptide linkage with a free alpha-amino group.

摘要

对从过敏性豚鼠肺扩散物中提取的嗜酸性粒细胞趋化因子A（ECF-A）制剂进行了多种酶降解处理。所使用的酶仅对其相应的底物具有特异性。用相对高剂量的胰蛋白酶、α-糜蛋白酶、链霉蛋白酶、碱性磷酸酶和唾液酸酶处理后未发现有影响。相反，与酪氨酸酶、芳基硫酸酯酶和亮氨酸氨肽酶孵育后，活性呈剂量依赖性丧失，这表明ECF-A含有一个酚羟基、一个硫酸酯和一个带有游离α-氨基的肽键。

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本文引用的文献

1
Tyrosine-O-sulfate as a constituent of normal human urine.酪氨酸 - O - 硫酸盐作为正常人尿液的一种成分。
J Biol Chem. 1955 Dec;217(2):703-8.
2
Glycoprotein coat of the TA 3 cell. I. Removal of carbohydrate and protein material from viable cells.TA 3细胞的糖蛋白衣。I. 从活细胞中去除碳水化合物和蛋白质物质。
J Natl Cancer Inst. 1970 Oct;45(4):637-47.
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Studies on eosinophil leucocyte migration. II. Factors specifically chemotactic for eosinophils and neutrophils generated from guinea-pig serum by antigen-antibody complexes.嗜酸性白细胞迁移的研究。II. 抗原抗体复合物从豚鼠血清中产生的对嗜酸性粒细胞和中性粒细胞具有特异性趋化作用的因子。
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Uptake and subcellular localization of tritiated spermine in Escherichia coli.氚标记精胺在大肠杆菌中的摄取及亚细胞定位
Arch Biochem Biophys. 1968 Oct;128(1):113-23. doi: 10.1016/0003-9861(68)90013-1.
5
Tumor-associated eosinophilotactic factor.肿瘤相关嗜酸性粒细胞趋化因子
N Engl J Med. 1974 Feb 21;290(8):420-4. doi: 10.1056/NEJM197402212900802.
6
Purification of neuraminidases from Vibrio Cholerae, Clostridium Perfringens and influenza virus by affinity chromatography.通过亲和层析法从霍乱弧菌、产气荚膜梭菌和流感病毒中纯化神经氨酸酶。
Biochem Biophys Res Commun. 1971 Jul 2;44(1):178-84. doi: 10.1016/s0006-291x(71)80175-4.
7
Selective attraction of eosinophils and synergism between eosinophil chemotactic factor of anaphylaxis (ECF-A) and a fragment cleaved from the fifth component of complement (C5a).嗜酸性粒细胞的选择性趋化作用以及过敏反应嗜酸性粒细胞趋化因子（ECF-A）与补体第五成分（C5a）裂解片段之间的协同作用。
Immunology. 1973 Jun;24(6):969-76.
8
On the nature of the presumed receptor for IgE on mast cells. I. The effect of sialidase and phospholipase C treatment on the capacity of rat peritoneal cells to participate in IgE-mediated, antigen-induced histamine release in vitro.关于肥大细胞上假定的IgE受体的性质。I. 唾液酸酶和磷脂酶C处理对大鼠腹膜细胞在体外参与IgE介导的、抗原诱导的组胺释放能力的影响。
J Immunol. 1973 Jun;110(6):1599-608.
9
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J Exp Med. 1971 Mar 1;133(3):602-19. doi: 10.1084/jem.133.3.602.

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