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超敏反应中组织嗜酸性粒细胞增多的介导作用。II. 从巨噬细胞趋化因子中分离出一种迟发型嗜酸性粒细胞趋化因子。

The mediation of tissue eosinophilia in hypersensitivity reactions. II. Separation of a delayed eosinophil chemotactic factor from macrophage chemotactic factors.

作者信息

Hirashima M, Honda M, Hayashi H

出版信息

Immunology. 1976 Aug;31(2):263-71.

PMID:955679
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1445113/
Abstract

In anaphylactic cutaneous lesions induced by DNP-ascaris extract in the guinea-pig, the time-course of delayed tissue eosinophilia was found to parallel that of the macrophage reaction, reaching its peak in 24 h. Macrophages could be differentiated from lymphocytes by the numerous lysosomal granules which stained for acid phosphatase. Extracts from such skin lesions contained a delayed eosinophil chemotactic factor and two different macrophage chemotactic factors. Most of the delayed eosinophil chemotactic factor was separated from the two macrophage chemotactic factors by gel filtration on Sephadex G-100 and Sephadex G-200 in that order. The eosinophil chemotactic factor after re-chromatography on Sephadex G-I99 showed no or little chemotactic activity for macrophages.

摘要

在豚鼠中由二硝基苯-蛔虫提取物诱导的过敏性皮肤损伤中，发现迟发性组织嗜酸性粒细胞增多的时间进程与巨噬细胞反应的时间进程平行，在24小时达到峰值。巨噬细胞可通过大量对酸性磷酸酶染色的溶酶体颗粒与淋巴细胞区分开来。此类皮肤损伤的提取物含有一种迟发性嗜酸性粒细胞趋化因子和两种不同的巨噬细胞趋化因子。大部分迟发性嗜酸性粒细胞趋化因子通过依次在葡聚糖凝胶G-100和葡聚糖凝胶G-200上进行凝胶过滤与两种巨噬细胞趋化因子分离。在葡聚糖凝胶G-199上重新层析后的嗜酸性粒细胞趋化因子对巨噬细胞没有或几乎没有趋化活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b414/1445113/4ec63161530b/immunology00295-0107-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b414/1445113/4ec63161530b/immunology00295-0107-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b414/1445113/4ec63161530b/immunology00295-0107-a.jpg

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2
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本文引用的文献

1
Proteolytic mechanism in recurrence of Arthus-type inflammation by thiol compounds.硫醇化合物引发阿瑟斯型炎症复发中的蛋白水解机制。
Br J Exp Pathol. 1962 Oct;43(5):564-73.
2
Antibody formation in vitro.体外抗体形成。
J Exp Med. 1961 Dec 1;114(6):837-56. doi: 10.1084/jem.114.6.837.
3
The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes.抗体与抗原混合物对多形核白细胞的趋化作用。
Characterization of three macrophage chemotactic factors from PPD-induced delayed hypersensitivity reaction sites in guinea pigs, with special reference to a chemotactic lymphokine.
豚鼠结核菌素纯蛋白衍生物诱导的迟发型超敏反应部位三种巨噬细胞趋化因子的特性分析，特别涉及一种趋化性淋巴因子。
Am J Pathol. 1982 Aug;108(2):171-83.
4
Selective chemotaxis of Ia antigen-positive blood monocytes in response to a macrophage chemotactic lymphokine extractable from PPD-induced delayed hypersensitivity reaction site in guinea-pigs.在豚鼠中，从PPD诱导的迟发型超敏反应部位可提取出一种巨噬细胞趋化性淋巴因子，Ia抗原阳性血液单核细胞对其产生选择性趋化作用。
Immunology. 1984 Jun;52(2):269-80.
5
Isolation of an eosinophil chemotactic lymphokine as a natural mediator for eosinophil chemotaxis from concanavalin A-induced skin reaction sites in guinea-pigs.从豚鼠伴刀豆球蛋白A诱导的皮肤反应部位分离出嗜酸性粒细胞趋化性淋巴因子作为嗜酸性粒细胞趋化作用的天然介质。
Clin Exp Immunol. 1984 Jul;57(1):211-9.
6
The regulation of tissue eosinophil chemotactic factor and inhibitor in allergic skin lesions of Freund's complete adjuvant-treated guinea-pigs.弗氏完全佐剂处理的豚鼠过敏性皮肤损伤中组织嗜酸性粒细胞趋化因子及抑制剂的调节
Immunology. 1984 Mar;51(3):441-50.
7
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Immunology. 1983 Jan;48(1):59-67.
8
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Immunology. 1985 May;55(1):115-24.
9
Dexamethasone suppresses concanavalin A-induced production of chemotactic lymphokines by releasing a soluble factor from splenic T lymphocytes.地塞米松通过从脾T淋巴细胞释放一种可溶性因子来抑制伴刀豆球蛋白A诱导的趋化性淋巴细胞因子的产生。
Immunology. 1985 Mar;54(3):533-40.
10
In vitro macrophage chemotactic generation from serum immunoglobulin G by neutrophil neutral seryl protease.嗜中性粒细胞中性丝氨酸蛋白酶从血清免疫球蛋白G体外生成巨噬细胞趋化因子。
Immunology. 1978 Jul;35(1):167-76.
J Exp Med. 1962 Mar 1;115(3):453-66. doi: 10.1084/jem.115.3.453.
4
Gel filtration: a method for desalting and group separation.凝胶过滤：一种脱盐和分组分离的方法。
Nature. 1959 Jun 13;183(4676):1657-9. doi: 10.1038/1831657a0.
5
The gel-filtration behaviour of proteins related to their molecular weights over a wide range.蛋白质的凝胶过滤行为与其在很宽范围内的分子量相关。
Biochem J. 1965 Sep;96(3):595-606. doi: 10.1042/bj0960595.
6
Regulation of homocytotropic antibody formation in the rat. I. Feed-back regulation by passively administered antibody.大鼠中亲同种细胞抗体形成的调节。I. 被动给予抗体的反馈调节。
J Immunol. 1971 Apr;106(4):1002-11.
7
Studies on eosinophil leucocyte migration. I. Eosinophil and neutrophil accumulation following antigen-antibody reactions in guinea-pig skin.嗜酸性白细胞迁移的研究。I. 豚鼠皮肤抗原抗体反应后嗜酸性粒细胞和中性粒细胞的聚集。
Clin Exp Immunol. 1970 Jan;6(1):75-86.
8
Studies on eosinophil leucocyte migration. II. Factors specifically chemotactic for eosinophils and neutrophils generated from guinea-pig serum by antigen-antibody complexes.嗜酸性白细胞迁移的研究。II. 抗原抗体复合物从豚鼠血清中产生的对嗜酸性粒细胞和中性粒细胞具有特异性趋化作用的因子。
Clin Exp Immunol. 1970 Nov;7(5):723-37.
9
Use of leukocyte chemotaxis in vitro to assay mediators generated by immune reactions. I. Quantitation of mononuclear and polymorphonuclear leukocyte chemotaxis with polycarbonate (nuclepore) filters.利用体外白细胞趋化性检测免疫反应产生的介质。I. 使用聚碳酸酯（核孔）滤膜对单核细胞和多形核白细胞趋化性进行定量分析。
J Immunol. 1971 Mar;106(3):649-55.
10
Peripheral blood eosinophilia in guinea-pigs following implantation of anaphylactic guinea-pig and human lung.
Br J Haematol. 1968 Apr;14(4):425-45. doi: 10.1111/j.1365-2141.1968.tb06994.x.