Shimizu M, Yamada S, Murakami Y, Morozumi T, Kobayashi H, Mitani K, Ito N, Kubo M, Kimura K, Kobayashi M
National Institute of Animal Health, Ibaraki, Japan.
J Vet Med Sci. 1994 Apr;56(2):389-91. doi: 10.1292/jvms.56.389.
Porcine reproductive and respiratory syndrome (PRRS) virus was isolated at high frequency from the sera and lungs of pigs affected with Heko-Heko disease. In addition, a considerable amount of Mycoplasma hyorhinis (Mhr) was also isolated from the lungs. Inoculation of gnotobiote pigs with the first isolate of PRRS virus resulted in the reproduction of proliferative and interstitial pneumonia. The virus was recovered from the inoculated pigs for long periods. Superinfection with PRRS virus and Mhr appeared to produce more serious pneumonia than inoculation with PRRS virus alone. In this study, the presence of PRRS virus was confirmed in Japan, and the PRRS virus was considered as being the most important pathogen for Heko-Heko disease.
猪繁殖与呼吸综合征（PRRS）病毒在患有赫赫病的猪的血清和肺中被高频分离出来。此外，还从肺中分离出了大量的猪鼻支原体（Mhr）。用第一株PRRS病毒接种无菌猪导致了增生性和间质性肺炎的再现。该病毒在接种猪体内长时间被检出。PRRS病毒和Mhr的双重感染似乎比单独接种PRRS病毒产生更严重的肺炎。在本研究中，在日本证实了PRRS病毒的存在，并且PRRS病毒被认为是赫赫病最重要的病原体。
