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Cloning and sequence of the Xenopus laevis homologue of the midkine cDNA.

作者信息

Fu C, Maminta-Smith L D, Guo C, Deuel T F

机构信息

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110.

出版信息

Gene. 1994 Sep 2;146(2):311-2. doi: 10.1016/0378-1119(94)90312-3.

DOI:10.1016/0378-1119(94)90312-3
PMID:8076838
Abstract

The Xenopus laevis (Xl) homologue of the midkine-encoding gene (MK) has been isolated and sequenced from a X. laevis cDNA library made from the head region of stage-22 embryo. The nucleotide and deduced amino-acid sequences show a high degree of conservation with the avian and mammalian MK and pleiotrophin (PTN) genes and gene products. Highly conserved domains may indicate important regions for the function of the MK and PTN proteins.

摘要

相似文献

1
Cloning and sequence of the Xenopus laevis homologue of the midkine cDNA.
Gene. 1994 Sep 2;146(2):311-2. doi: 10.1016/0378-1119(94)90312-3.
2
Restricted expression of Xenopus midkine gene during early development.非洲爪蟾中期因子基因在早期发育过程中的表达受限。
J Biochem. 1995 Jul;118(1):94-100. doi: 10.1093/oxfordjournals.jbchem.a124898.
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A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.一类新的肝素结合因子:人源和鼠源中期因子(MK)序列高度保守。
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5
Midkine regulates pleiotrophin organ-specific gene expression: evidence for transcriptional regulation and functional redundancy within the pleiotrophin/midkine developmental gene family.中期因子调节多效生长因子器官特异性基因表达:多效生长因子/中期因子发育基因家族内转录调控和功能冗余的证据。
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6
Midkine and pleiotrophin have bactericidal properties: preserved antibacterial activity in a family of heparin-binding growth factors during evolution.中期因子和多效生长因子具有杀菌特性:在进化过程中,肝素结合生长因子家族中保持了抗菌活性。
J Biol Chem. 2010 May 21;285(21):16105-15. doi: 10.1074/jbc.M109.081232. Epub 2010 Mar 22.
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Developmental and differential regulations in gene expression of Xenopus pleiotrophic factors-alpha and -beta.非洲爪蟾多效因子-α和-β基因表达中的发育调控与差异调控。
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Cloning, nucleotide sequence, and chromosome localization of the human pleiotrophin gene.人类多效生长因子基因的克隆、核苷酸序列及染色体定位
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The sequence of a Xenopus laevis TFIID subunit reveals remarkable conservation among vertebrates.
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The midkine (MK) family of growth/differentiation factors: structure of an MK-related sequence in a pseudogene and evolutionary relationships among members of the MK family.生长/分化因子的中期因子(MK)家族:假基因中与MK相关序列的结构以及MK家族成员间的进化关系。
J Biochem. 1994 Mar;115(3):516-22. doi: 10.1093/oxfordjournals.jbchem.a124368.

引用本文的文献

1
From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.从顶部到底部:中期因子和多效生长因子作为免疫调节中的新兴参与者。
J Leukoc Biol. 2017 Aug;102(2):277-286. doi: 10.1189/jlb.3MR1116-475R. Epub 2017 Mar 29.
2
Early Disruption of Extracellular Pleiotrophin Distribution Alters Cerebellar Neuronal Circuit Development and Function.细胞外多效蛋白分布的早期破坏会改变小脑神经元回路的发育和功能。
Mol Neurobiol. 2016 Oct;53(8):5203-16. doi: 10.1007/s12035-015-9450-5. Epub 2015 Sep 24.
3
The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.
果蝇中肾素/多效生长因子同系物Miple1和Miple2影响成虫寿命,但在胚胎肠道形成过程中对alk信号传导并非必需。
PLoS One. 2014 Nov 7;9(11):e112250. doi: 10.1371/journal.pone.0112250. eCollection 2014.
4
Midkine: a promising molecule for drug development to treat diseases of the central nervous system.中期因子:一种有前途的药物开发分子,可用于治疗中枢神经系统疾病。
Curr Pharm Des. 2011;17(5):410-23. doi: 10.2174/138161211795164167.