Weiss N, Delius M, Gambihler S, Eichholtz-Wirth H, Dirschedl P, Brendel W
Institute of Surgical Research, Klinikum Grosshadern, University of Munich, Germany.
Int J Cancer. 1994 Sep 1;58(5):693-9. doi: 10.1002/ijc.2910580513.
The effect of a combination of shock waves with cisplatin was examined in vivo with subcutaneously implanted amelanotic melanomas (A-Mel 3) in Syrian golden hamsters and cisplatin-sensitive or cisplatin-resistant fibrosarcoma (SSK2/0 and SSK2/R2) in C3H mice. In all 3 tumor models, 4 treatment modalities were compared: control, cisplatin treatment, shock waves and the combination of shock waves and cisplatin. Shock waves significantly delayed tumor growth in all 3 tumor models when compared to the respective control group. Cisplatin alone delayed the growth of A-Mel 3 and SSK2/0, whereas SSK2/R2 remained uninfluenced by the drug. In all 3 tumor models the combined treatment with shock waves and cisplatin additively and significantly delayed tumor growth. In A-Mel-3-bearing animals the combined treatment significantly increased survival time. The growth of SSK2/0 and SSK2/R2 tumors was delayed to a similar extent by the combined treatment modality as compared to shock-wave treatment alone. This indicates that the cisplatin resistance of SSK2/R2 tumors has been overcome by the simultaneous shock wave treatment. An increased intracellular cisplatin accumulation in the tumors due to shock wave exposure is suggested as the mechanism of interaction between shock waves and cisplatin.
在叙利亚金黄地鼠皮下植入无黑色素黑色素瘤（A-Mel 3）以及在C3H小鼠中植入顺铂敏感或顺铂耐药的纤维肉瘤（SSK2/0和SSK2/R2），以此在体内研究冲击波与顺铂联合使用的效果。在所有这3种肿瘤模型中，比较了4种治疗方式：对照组、顺铂治疗、冲击波以及冲击波与顺铂联合治疗。与各自的对照组相比，冲击波在所有3种肿瘤模型中均显著延缓了肿瘤生长。单独使用顺铂延缓了A-Mel 3和SSK2/0的生长，而SSK2/R2对该药物无反应。在所有3种肿瘤模型中，冲击波与顺铂联合治疗相加并显著延缓了肿瘤生长。在携带A-Mel-3的动物中，联合治疗显著延长了生存时间。与单独的冲击波治疗相比，联合治疗方式使SSK2/0和SSK2/R2肿瘤的生长延缓程度相似。这表明同时进行的冲击波治疗克服了SSK2/R2肿瘤的顺铂耐药性。由于冲击波暴露导致肿瘤细胞内顺铂积累增加，这被认为是冲击波与顺铂之间相互作用的机制。
