Lee K E, Smith P, Cockett A T
Department of Urology, University of Rochester, School of Medicine, New York.
Urology. 1990 Nov;36(5):440-4. doi: 10.1016/s0090-4295(90)80292-u.
The potential application of high-energy shock waves (HESW) for control of experimental bladder cancer was investigated. Subcutaneous 3-d murine bladder cancer (MBT-2) in C3H mice were exposed to HESW alone (250 to 1,500 shocks) or in combination with cisplatin (5 to 10 mg/kg, i.p.). Although HESW alone showed no influence on tumor growth, HESW/cisplatin combination therapy suppressed tumor growth more than cisplatin alone. Subsequent studies revealed that an air-fluid interface relative to tumor location played a pivotal role for the chemosensitizing effect of HESW. HESW treatment was able to enhance the cisplatin cytotoxicity only when the tumors were placed adjacent to the air-fluid interface.
研究了高能冲击波（HESW）在控制实验性膀胱癌方面的潜在应用。将C3H小鼠皮下接种的3 - d龄鼠膀胱癌（MBT - 2）单独暴露于HESW（250至1500次冲击）或与顺铂（5至10 mg/kg，腹腔注射）联合使用。虽然单独使用HESW对肿瘤生长没有影响，但HESW/顺铂联合治疗比单独使用顺铂更能抑制肿瘤生长。随后的研究表明，相对于肿瘤位置的气液界面在HESW的化学增敏作用中起关键作用。只有当肿瘤位于气液界面附近时，HESW治疗才能增强顺铂的细胞毒性。
