Conville P S, Witebsky F G, MacLowry J D
Clinical Pathology Department, Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892.
J Clin Microbiol. 1994 Jun;32(6):1554-9. doi: 10.1128/jcm.32.6.1554-1559.1994.
The DAWN Model B laser light scattering instrument (Wyatt Technology Corporation, Santa Barbara, Calif.) was evaluated to assess its potential to provide rapid mycobacterial antimicrobial susceptibility test results. For Mycobacterium tuberculosis there was a clear separation between susceptible and resistant results with the isolates tested, and there was excellent correlation with reference laboratory results. For Mycobacterium avium there was no obvious breakpoint between susceptible and resistant results with the isolates tested, and correlation with reference laboratory results was less good than for M. tuberculosis. However, for M. avium there was also less agreement among reference laboratory results than for M. tuberculosis. Significant instrument design and software program changes would be required for the instrument to become a useful tool for mycobacterial susceptibility testing in the diagnostic laboratory.
对DAWN Model B激光光散射仪（怀亚特技术公司，加利福尼亚州圣巴巴拉）进行了评估，以评估其提供快速分枝杆菌抗菌药敏试验结果的潜力。对于结核分枝杆菌，在所测试的分离株中，敏感和耐药结果之间有明显区分，并且与参考实验室结果具有良好的相关性。对于鸟分枝杆菌，在所测试的分离株中，敏感和耐药结果之间没有明显的断点，并且与参考实验室结果的相关性不如结核分枝杆菌。然而，与结核分枝杆菌相比，鸟分枝杆菌参考实验室结果之间的一致性也较低。要使该仪器成为诊断实验室中分枝杆菌药敏试验的有用工具，需要对仪器设计和软件程序进行重大更改。
