Branch C A, Goldberg D A, Ewing J R, Fagan S C, Butt S S, Gayner J
Department of Neurology, Henry Ford Hospital, Detroit, Michigan.
J Toxicol Environ Health. 1994 Sep;43(1):25-35. doi: 10.1080/15287399409531901.
The gaseous fluorocarbon trifluoromethane has recently been investigated for its potential as an in vivo gaseous indicator for nuclear magnetic resonance studies of brain perfusion. Trifluoromethane may also have significant value as a replacement for chlorofluorocarbon fire retardants. Because of possible species-specific cardiotoxic and anesthetic properties, the toxicological evaluation of trifluoromethane in primates (Papio anubis) is necessary prior to its evaluation in humans. We report the acute cardiac and central nervous system effects of trifluoromethane in eight anesthetized baboons. A dose-response effect was established for respiratory rate, electroencephalogram, and cardiac sinus rate, which exhibited a stepwise decrease from 10% trifluoromethane. No spontaneous arrhythmias were noted, and arterial blood pressure remained unchanged at any inspired level. Intravenous epinephrine infusions (1 microgram/kg) induced transient cardiac arrhythmia in 1 animal only at 70% FC-23 (v/v) trifluoromethane. Trifluoromethane appears to induce mild dose-related physiological changes at inspired levels of 30% or more, indicative of an anesthetic effect. These data suggest that trifluoromethane may be safe to use in humans, without significant adverse acute effects, at an inspired level of 30%.
气态碳氟化合物三氟甲烷最近因其作为用于脑灌注核磁共振研究的体内气态指示剂的潜力而受到研究。三氟甲烷作为氯氟烃阻燃剂的替代品也可能具有重要价值。由于可能存在物种特异性的心脏毒性和麻醉特性，在对人类进行评估之前，有必要对灵长类动物（埃及狒狒）进行三氟甲烷的毒理学评估。我们报告了三氟甲烷对八只麻醉狒狒的急性心脏和中枢神经系统影响。确定了呼吸频率、脑电图和心脏窦性心率的剂量反应效应，从10%三氟甲烷开始呈逐步下降。未观察到自发性心律失常，在任何吸入水平下动脉血压均保持不变。仅在70% FC - 23（体积/体积）三氟甲烷时，静脉注射肾上腺素（1微克/千克）仅在1只动物中诱发了短暂性心律失常。在吸入水平达到30%或更高时，三氟甲烷似乎会诱发轻度的剂量相关生理变化，表明具有麻醉作用。这些数据表明，在吸入水平为30%时，三氟甲烷用于人类可能是安全的，不会产生明显的急性不良反应。
