Lessard Y, Desbrousses S, Paulet G
C R Seances Soc Biol Fil. 1977;171(4):883-95.
Inhalation of gas mixtures containing different concentrations of FC12 by anesthetized and normally oxygenated rabbits produces blood levels of FC12 which are stable and proportional to the rate of FC12 in the mixture. From the arterial concentration of 80 microgram/ml FC12 (10 % FC12) mixture) and over, FC12 alone causes effects proportional to doses: arterial pressure decrease with tachycardia; slight morphological alterations of the electrocardiogram at high concentration. Arrhythmia never occurs under the action of FC12 alone even at maximum arterial concentration reached here: 235 microgram/ml (40 % FC12 mixture). Recorded disturbances are always reversible. The intravenous perfusion of epinephrine alone evokes the appearance of premature contractions at only very high doses: 12 microgram/kg/min. The presence of FC12 in blood conjoined with epinephrine induces the inhibition of the hypertensive action of epinephrine at high concentrations and lowers the arrhythmogenic threshold. Both parameters interfere: the arrhythmogenic dose of epinephrine is a function of blood levels of FC12.
给麻醉且正常吸氧的兔子吸入含有不同浓度FC12的混合气体后，血液中的FC12水平稳定，且与混合气体中FC12的比例成正比。当动脉血中FC12浓度达到80微克/毫升（10%的FC12混合气体）及以上时，单独的FC12会产生与剂量成正比的效应：动脉压下降并伴有心动过速；高浓度时心电图会出现轻微形态改变。即使在此处达到的最大动脉血浓度（235微克/毫升，40%的FC12混合气体）下，单独使用FC12时也从未发生心律失常。记录到的异常总是可逆的。单独静脉注射肾上腺素时，只有在非常高的剂量（12微克/千克/分钟）下才会诱发早搏。血液中存在FC12并与肾上腺素结合时，在高浓度下会抑制肾上腺素的升压作用，并降低致心律失常阈值。这两个参数相互干扰：肾上腺素的致心律失常剂量是血液中FC12水平的函数。
