Lessard Y, Desbrousses S, Paulet G
C R Seances Soc Biol Fil. 1977;171(6):1270-82.
Inhalation of gas mixtures containing different concentrations of FC 12 by anesthetized and normally oxygenated dogs produces blood levels of FC 12 which are stable and proportional to the rate of FC 12 in the mixture. From the arterial concentration of 40 microgram/ml FC 12 (5 % FC 12 mixture) and over, FC 12 alone causes effects proportional to doses: arterial pressure decrease with tachycardia. At high rates of FC 12 tachypnoea and slight morphological alterations of the electrocardiogram can be recorded. Arhythmia never occurs under the action of FC 12 alone even at maximum arterial concentration reached here : 230 microgram/ml (40 % FC 12 mixture). Recorded disturbances are always reversible. The intravenous perfusion of epinephrine alone evokes the appearance of premature contractions at the only dose of 5 microgram/kg/mn. The presence of FC 12 in blood conjoined with epinephrine induces the inhibition of the hypertensive action of epinephrine at high concentration and lowers the arhythmogenic threshold. The dog is clearly more sensitive than the rabbit to the arhythmogenic action of epinephrine and FC 12. The required rates of epinephrine and FC 12 validate the hypothesis of cardiac sensitization by FC 12 to the arhythmogenic action of circulating adrenaline to explain the cases of sudden "sniffing" deaths in man.
给麻醉且正常吸氧的狗吸入含不同浓度氟利昂12（FC 12）的气体混合物后，血液中的FC 12水平稳定，且与混合物中FC 12的速率成正比。当动脉血中FC 12浓度达到40微克/毫升（5% FC 12混合物）及以上时，仅FC 12就会产生与剂量成正比的效应：动脉压下降并伴有心动过速。在高FC 12速率时，可记录到呼吸急促和心电图的轻微形态改变。即使在此处达到的最大动脉血浓度230微克/毫升（40% FC 12混合物）下，单独使用FC 12时也从未发生心律失常。记录到的干扰总是可逆的。仅静脉输注肾上腺素时，仅在5微克/千克/分钟的剂量下就会引发早搏。血液中FC 12与肾上腺素同时存在时，在高浓度下会抑制肾上腺素的升压作用，并降低致心律失常阈值。狗对肾上腺素和FC 12的致心律失常作用明显比兔子更敏感。所需的肾上腺素和FC 12速率证实了FC 12使心脏对循环中肾上腺素的致心律失常作用敏感化的假说，以解释人类突然“嗅吸”死亡的病例。
