乙肝高度流行地区慢性肝病患者中的丙型肝炎病毒感染
Hepatitis C virus infection among patients with chronic liver disease in an area hyperendemic for hepatitis B.
作者信息
Tsai J F, Jeng J E, Chang W Y, Lin Z Y, Tsai J H
机构信息
Dept. of Internal Medicine, Kaohsiung Medical College, Taiwan.
出版信息
Scand J Gastroenterol. 1994 Jun;29(6):550-2. doi: 10.3109/00365529409092471.
BACKGROUND
The prevalence of hepatitis C virus (HCV) infection was assessed in patients with non-alcoholic chronic liver disease (CLD).
METHODS
Antibody levels to HCV (anti-HCV) were assessed in 100 pairs of CLD patients and healthy controls.
RESULTS
The prevalence of anti-HCV was higher in patients (26.0%) than in controls (2.0%; p = 0.0001). The patient group with anti-HCV was older (p = 0.0001) and had more smokers (p = 0.034), fewer hepatitis B surface antigen carriers (p = 0.0001), and more patients with active liver disease (p = 0.023) and a history of blood transfusion (p = 0.026). Multivariate analysis showed that anti-HCV (odds ratio, 8.1; 95% confidence intervals, 3.7-17.6) was strongly associated with CLD.
CONCLUSIONS
HCV infection is a risk factor of non-alcoholic CLD, and HCV causes more severe hepatocellular damage than HBV.
背景
对非酒精性慢性肝病（CLD）患者的丙型肝炎病毒（HCV）感染率进行了评估。
方法
对100对CLD患者和健康对照者进行了HCV抗体水平（抗-HCV）评估。
结果
患者中抗-HCV的患病率（26.0%）高于对照组（2.0%；p = 0.0001）。抗-HCV的患者组年龄更大（p = 0.0001），吸烟者更多（p = 0.034），乙肝表面抗原携带者更少（p = 0.0001），活动性肝病患者更多（p = 0.023），有输血史的患者更多（p = 0.026）。多因素分析显示，抗-HCV（比值比，8.1；95%置信区间，3.7 - 17.6）与CLD密切相关。
结论
HCV感染是非酒精性CLD的一个危险因素，且HCV比HBV导致更严重的肝细胞损伤。
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