Holmen J
Samfunnsmedisinsk forskningssenter, Statens Institutt for Folkehelse, Verdal.
Tidsskr Nor Laegeforen. 1994 Jun 10;114(15):1700-3.
The term reduced glucose tolerance is often used to describe an intermediate phase between normal glucose metabolism and diabetes, and WHO discriminates between type 2 diabetes and reduced glucose tolerance. However, biologically there is no clear distinction between the two groups. As a biological phenomenon reduced glucose tolerance is important because it is a risk factor for cardiovascular disease. The article describes reduced glucose tolerance as a part of the metabolic cardiovascular syndrome, and several models which might help to explain some of the mechanisms. The distribution of musculoskeletal fibres, the impact of physical activity, and the relation between insulin and blood pressure, lipids and the disposition for thrombosis, are discussed. Genetic disposition is also an important factor. The research in this field is rapidly increasing, and a survey can only be a snapshot. However, greater understanding of the mechanisms linking reduced glucose tolerance and the metabolic cardiovascular syndrome is a strong argument to focussing the total risk profile, and not only, single risk factors, in preventive cardiovascular medicine.
糖耐量降低这一术语常被用于描述正常葡萄糖代谢与糖尿病之间的中间阶段，世界卫生组织对2型糖尿病和糖耐量降低进行了区分。然而，从生物学角度来看，这两组之间并没有明确的区别。作为一种生物学现象，糖耐量降低很重要，因为它是心血管疾病的一个危险因素。本文将糖耐量降低描述为代谢性心血管综合征的一部分，并介绍了一些可能有助于解释部分机制的模型。文中讨论了肌肉骨骼纤维的分布、体育活动的影响以及胰岛素与血压、血脂和血栓形成倾向之间的关系。遗传易感性也是一个重要因素。该领域的研究正在迅速增加，本综述只能是一个简要概述。然而，更深入地了解将糖耐量降低与代谢性心血管综合征联系起来的机制，有力地支持了在预防性心血管医学中关注整体风险状况，而不仅仅是单一风险因素。
