Bertazzolo N, Punzi L, Stefani M P, Cesaro G, Pianon M, Finco B, Todesco S
Division of Rheumatology, University of Padova, Italy.
Agents Actions. 1994 Mar;41(1-2):90-2. doi: 10.1007/BF01986402.
High levels of many cytokines, including interleukin (IL)-1, IL-6 and IL-8, were found in various arthropathies suggesting that they play a role in the pathogenesis of disease, although their relationship with the type and activity of disease is still not clear. The synovial fluid (SF) of 24 patients with rheumatoid arthritis (RA), 19 with psoriatic arthritis (PA) and 33 with osteoarthritis (OA) was analyzed for IL-1 beta, IL-6 and IL-8. The highest concentration of the three cytokines was found in the SF of RA. IL-beta detectable levels (> or = 20 pg/ml) were observed in 8/24 (33.3%) patients with RA, in one patient with PA but in no patient with OA. IL-6 (mean +/- SD) (1610.37 +/- 1781.65 pg/ml) was higher in RA than in PA (672.47 +/- 867.40 pg/ml, p = 0.043) and OA (89.45 +/- 120.52 pg/ml, p = 0.0001). IL-8 (1042.72 +/- 698.64 pg/ml) was higher in RA than in PA (660.36 +/- 625.11 pg/ml, p = 0.03) and OA (89.9 +/- 45.88 pg/ml, p = 0.0001). A correlation between IL-1 beta, IL-6 and IL-8 was found in RA. In all patients a correlation between IL-6 and IL-8 levels was found; moreover, these two cytokines were associated with SF indices of inflammation, such as white blood cells (WBC) count and total protein (TP) concentration. Our findings suggest that these interrelationships play a role in the evolution of more severe erosive arthropathy such as RA.
在各种关节病中发现包括白细胞介素（IL）-1、IL-6和IL-8在内的多种细胞因子水平升高，这表明它们在疾病发病机制中发挥作用，尽管它们与疾病类型和活动度的关系仍不明确。对24例类风湿关节炎（RA）患者、19例银屑病关节炎（PA）患者和33例骨关节炎（OA）患者的滑液（SF）进行了IL-1β、IL-6和IL-8分析。三种细胞因子的最高浓度在RA的滑液中被发现。在8/24（33.3%）例RA患者中观察到可检测到的IL-β水平（≥20 pg/ml），1例PA患者中观察到，但OA患者中未观察到。RA患者的IL-6（均值±标准差）（1610.37±1781.65 pg/ml）高于PA患者（672.47±867.40 pg/ml，p = 0.043）和OA患者（89.45±120.52 pg/ml，p = 0.0001）。RA患者的IL-8（1042.72±698.64 pg/ml）高于PA患者（660.36±625.11 pg/ml，p = 0.03）和OA患者（89.9±45.88 pg/ml，p = 0.0001）。在RA中发现IL-1β、IL-6和IL-8之间存在相关性。在所有患者中发现IL-6和IL-8水平之间存在相关性；此外，这两种细胞因子与炎症的滑液指标相关，如白细胞（WBC）计数和总蛋白（TP）浓度。我们的研究结果表明，这些相互关系在更严重的侵蚀性关节病如RA的发展中发挥作用。
