体内铁储备对血液透析患者血清促红细胞生成素浓度的影响。

Influence of body iron stores on the serum erythropoietin concentration in hemodialyzed patients.

作者信息

Teruel J L, Marcen R, Navarro J F, Villafruela J J, Fernandez Lucas M, Rivera M, Ortuño J

机构信息

Department of Nephrology, Hospital Ramón y Cajal, Madrid, Spain.

出版信息

Am J Nephrol. 1994;14(2):95-8. doi: 10.1159/000168696.

DOI:10.1159/000168696

PMID:8080013

Abstract

The influence of body iron stores on the concentration of serum erythropoietin was studied in 48 hemodialyzed patients not receiving human recombinant erythropoietin, androgens or iron supplements. The serum erythropoietin concentration was 11.6 +/- 10.4 mIU/ml. There was no correlation between the serum erythropoietin and the hematocrit or hemoglobin concentration; however, there was a correlation between the serum erythropoietin and the log of serum ferritin (r = -0.5699, p < 0.01). Serum erythropoietin levels were higher in the 18 ferropenic patients (serum ferritin < 50 ng/ml) than in the 30 patients with normal serum ferritin concentration (18 +/- 13.8 vs. 7.8 +/- 4.7 mIU/ml, p < 0.01). The administration of intravenous iron to the ferropenic patients resulted in a reduction in serum erythropoietin independent of the response of the anemia (18 +/- 13.8 basal and 7.9 +/- 6.5 mIU/ml at 4 weeks, p < 0.01). Our data would suggest that the concentration of erythropoietin in hemodialyzed patients is influenced by the serum ferritin level.

摘要

在48例未接受重组人促红细胞生成素、雄激素或铁补充剂的血液透析患者中，研究了机体铁储备对血清促红细胞生成素浓度的影响。血清促红细胞生成素浓度为11.6±10.4 mIU/ml。血清促红细胞生成素与血细胞比容或血红蛋白浓度之间无相关性；然而，血清促红细胞生成素与血清铁蛋白的对数之间存在相关性（r = -0.5699，p < 0.01）。18例铁缺乏患者（血清铁蛋白<50 ng/ml）的血清促红细胞生成素水平高于30例血清铁蛋白浓度正常的患者（18±13.8 vs. 7.8±4.7 mIU/ml，p < 0.01）。给铁缺乏患者静脉注射铁剂导致血清促红细胞生成素降低，与贫血反应无关（基础值为18±13.8，4周时为7.9±6.5 mIU/ml，p < 0.01）。我们的数据表明，血液透析患者促红细胞生成素的浓度受血清铁蛋白水平的影响。