Czernichow P, Dauzet M C, Broyer M, Rappaport R
J Clin Endocrinol Metab. 1976 Sep;43(3):630-7. doi: 10.1210/jcem-43-3-630.
TSH, PRL and GH response to TSH releasing factor as well as basal T4 and T3 were evaluated in a group of patients with chronic renal failure undergoing chronic hemodialysis. Serum T4 and T3 were lower than normal. Basal TSH was normal as compared to control, but did not rise after TRF stimulation. Larger dosages of TRF did not correct this abnormal response. Basal PRL was higher than control and remained at the same level during the test. GH was stimulated by the TRF with a peak occurring 20 min after injection. This abnormal secretion was not blunted by T3 administration. TRF half-life measured in 3 patients was 4 min. These data indicate that 1) there is an abnormal response to TRF in chronic renal failure which does not seem to be due to an altered sensitivity to, or metabolism of TRF; and 2) there is an abnormal TSH secretion which may be responsible for the low T4 and T3 measured in these patients.
对一组接受慢性血液透析的慢性肾衰竭患者，评估了促甲状腺激素（TSH）、催乳素（PRL）和生长激素（GH）对促甲状腺激素释放因子（TRF）的反应以及基础甲状腺素（T4）和三碘甲状腺原氨酸（T3）水平。血清T4和T3低于正常水平。与对照组相比，基础TSH正常，但TRF刺激后不升高。较大剂量的TRF不能纠正这种异常反应。基础PRL高于对照组，且在测试期间保持在同一水平。TRF刺激了GH分泌，注射后20分钟出现峰值。给予T3并未减弱这种异常分泌。对3例患者测得的TRF半衰期为4分钟。这些数据表明：1）慢性肾衰竭患者对TRF存在异常反应，这似乎并非由于对TRF的敏感性改变或其代谢异常所致；2）存在异常的TSH分泌，这可能是这些患者测得的T4和T3水平降低的原因。
