接受血液透析的慢性肾衰竭儿童对促甲状腺激素释放激素的促甲状腺激素和催乳素反应
TSH and PRL response to thyrotrophin-releasing hormone in children with chronic renal failure undergoing haemodialysis.
作者信息
Ijaiya K
出版信息
Arch Dis Child. 1979 Dec;54(12):937-41. doi: 10.1136/adc.54.12.937.
Abstract
Eight children (aged between 8 1/2 and 15 1/2 years) with chronic renal failure receiving intermittent haemodialysis, and 2 children with renal transplants were studied. The response of TSH and prolactin (PRL), and basal T4 and T3 values was measured. Basal TSH was normal, and rose only slightly after TRH stimulation. Plasma T4 and T3 were below normal levels in 6 children. Mean basal PRL was raised and could not be stimulated by TRH. This study demonstrates the involvement of the hypothalamus and pituitary in chronic renal disease. The cause of the abnormal secretion of TSH and PRL in chronic renal failure is discussed in the light of clinical importance.
摘要
对8名接受间歇性血液透析的慢性肾衰竭儿童（年龄在8.5至15.5岁之间）以及2名肾移植儿童进行了研究。测量了促甲状腺激素（TSH）和催乳素（PRL）的反应以及基础甲状腺素（T4）和三碘甲状腺原氨酸（T3）值。基础TSH正常，促甲状腺激素释放激素（TRH）刺激后仅略有升高。6名儿童的血浆T4和T3低于正常水平。平均基础PRL升高，且TRH不能刺激其升高。本研究证明了下丘脑和垂体参与慢性肾病。根据临床重要性讨论了慢性肾衰竭中TSH和PRL分泌异常的原因。
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TSH and PRL response to thyrotrophin-releasing hormone in children with chronic renal failure undergoing haemodialysis.接受血液透析的慢性肾衰竭儿童对促甲状腺激素释放激素的促甲状腺激素和催乳素反应
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