Jacobs E J, White E, Weiss N S
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98104.
Cancer Causes Control. 1994 Jul;5(4):359-66. doi: 10.1007/BF01804987.
The associations between exogenous hormones, reproductive history, and colon cancer were investigated in a case-control study among women aged 30-62 years. The study was conducted in the Seattle, Washington (USA) metropolitan area between 1985 and 1989 and included 193 incident cases of colon cancer and 194 controls. There was little overall association between colon cancer and oral contraceptive use, parity, age at first birth, hysterectomy or oophorectomy status, or age at menopause. Use of noncontraceptive hormones at or after age 40, most likely hormone replacement therapy (HRT), was associated with decreased risk of colon cancer (adjusted odds ratio [OR] = 0.60, 95 percent confidence interval [CI] = 0.35-1.01), particularly among women with more than five years of use (OR = 0.47, 95 percent CI = 0.24-0.91). While results from previous studies have not been consistent, any protective effect of HRT against colon cancer would be important given the continuing debate over its potential risks and benefits.
在一项针对30至62岁女性的病例对照研究中，对外源性激素、生殖史与结肠癌之间的关联进行了调查。该研究于1985年至1989年在美国华盛顿州西雅图市大都市区开展，纳入了193例结肠癌新发病例和194例对照。结肠癌与口服避孕药的使用、产次、初产年龄、子宫切除术或卵巢切除术状态以及绝经年龄之间总体关联不大。40岁及以后使用非避孕激素，最有可能是激素替代疗法（HRT），与结肠癌风险降低相关（调整后的优势比[OR]=0.60，95%置信区间[CI]=0.35-1.01），尤其是在使用超过五年的女性中（OR=0.47，95%CI=0.24-0.91）。虽然以往研究结果并不一致，但鉴于对HRT潜在风险和益处的持续争论，HRT对结肠癌的任何保护作用都将具有重要意义。
