Kampman E, Bijl A J, Kok C, van't Veer P
TNO Nutrition and Food Research Institute, Zeist, The Netherlands.
Eur J Cancer Prev. 1994 Jul;3(4):329-36. doi: 10.1097/00008469-199407000-00005.
We analysed data from a case-control study in the Netherlands in order to investigate whether reproductive events and hormonal factors are similarly related to colon cancer risk in men and women after adjustment for dietary factors. In total, 232 colon cancer cases (102 women, 130 men) and 259 controls (123 women, 136 men) were interviewed about life style, medical conditions and usual dietary patterns, using a structured dietary history technique. In women, age at first childbirth was positively associated with colon cancer risk (odds ratio (OR) age > or = 26 vs < 26 years, 1.7; 95% confidence interval (CI), 0.9-3.3). Women with three or more children were at reduced risk compared with women with one or two children (OR, 0.6; 95% CI, 0.3-1.1). When women had had their first child after the age of 26 years, parity was observed to be important (for one or two children vs > or = three children: OR, 2.8; 95% CI, 1.1-7.0). For men, opposite but non-significant associations were found. Adjustment for dietary patterns and other risk factors did not change the estimates markedly. Of the hormonal factors, late age at menarche decreased risk (OR, 0.5; 95% CI, 0.3-0.9) while late age at natural menopause slightly increased risk. Our study provides additional support for the role of reproductive status in the aetiology of colon cancer in women, independently of dietary factors.
我们分析了荷兰一项病例对照研究的数据，以调查在调整饮食因素后，生殖事件和激素因素与男性和女性结肠癌风险的关联是否相似。总共对232例结肠癌病例（102名女性，130名男性）和259名对照者（123名女性，136名男性）进行了访谈，采用结构化饮食史技术询问他们的生活方式、健康状况和通常的饮食模式。在女性中，初产年龄与结肠癌风险呈正相关（比值比（OR）：年龄≥26岁与＜26岁相比，为1.7；95%置信区间（CI），0.9 - 3.3）。有三个或更多孩子的女性与有一个或两个孩子的女性相比，风险降低（OR，0.6；95% CI，0.3 - 1.1）。当女性在26岁以后生育第一胎时，产次被认为很重要（有一个或两个孩子与≥三个孩子相比：OR，2.8；95% CI，1.1 - 7.0）。对于男性，发现了相反但不显著的关联。调整饮食模式和其他风险因素后，估计值没有明显变化。在激素因素方面，初潮年龄晚降低了风险（OR，0.5；95% CI，0.3 - 0.9），而自然绝经年龄晚则略有增加风险。我们的研究为生殖状况在女性结肠癌病因学中的作用提供了额外支持，且独立于饮食因素。
