Handforth A, Cheng J T, Mandelkern M A, Treiman D M
Neurology Division, Department of Veterans Affairs Medical Center, West Los Angeles, CA 90073.
Epilepsia. 1994 Jul-Aug;35(4):876-81. doi: 10.1111/j.1528-1157.1994.tb02526.x.
The pathophysiologic and clinical significance of periodic lateralized epileptiform discharges (PLEDs) is unclear; whether PLEDs represent an ictal condition that should be treated remains uncertain. We performed FDG-positron emission computed tomography (FDG-PET) in a patient with PLEDs at 3 days, 18 days, and 10 weeks after onset. During left temporal PLEDs, the initial scan showed intense hypermetabolism of the left mesiotemporal region. The second scan, performed when PLEDs were resolving, displayed reduced hypermetabolism. The follow-up scan, when PLEDs had resolved, showed left temporal hypometabolism. These findings, together with clinical evidence from the literature, are compatible with the interpretation that PLEDs represent partial status epilepticus (SE); whether vigorous therapy is required to prevent neuronal damage from this focal seizure activity remains uncertain.
周期性一侧性癫痫样放电（PLEDs）的病理生理及临床意义尚不清楚；PLEDs是否代表一种需要治疗的发作状态仍不确定。我们对一名PLEDs患者在发病后3天、18天和10周进行了氟代脱氧葡萄糖正电子发射计算机断层扫描（FDG-PET）。在左侧颞叶PLEDs发作期间，首次扫描显示左侧颞叶内侧区域强烈代谢亢进。在PLEDs消退时进行的第二次扫描显示代谢亢进减轻。当PLEDs消退时的随访扫描显示左侧颞叶代谢减退。这些发现，连同文献中的临床证据，与PLEDs代表部分性癫痫持续状态（SE）的解释相符；是否需要积极治疗以防止这种局灶性癫痫发作活动导致神经元损伤仍不确定。
