Sandyk R, Derpapas K
NeuroCommunication Research Laboratories, Danbury, CT 06811.
Int J Neurosci. 1993 May;70(1-2):85-96. doi: 10.3109/00207459309000564.
We report a 68 year old man with a 7 year history of Parkinson's disease (PD) who obtained little benefit from treatment by dopaminergic and anticholinergic agents. During the six months prior to presentation, he experienced more rapid deterioration in symptoms including memory functions, increasing depression, and dystonia of the foot. External application of picoTesla range magnetic fields (MF) resulted in rapid attenuation of tremor and foot dystonia with improvements in gait, postural reflexes, mood, anxiety, cognitive, and autonomic functions. Plasma prolactin and luteinizing hormone (LH) levels rose three days after initiation of treatment. In addition, distinct electroencephalographic (EEG) changes were recorded nine days after two treatments with MF and included enhancement of alpha and beta activities as well as resolution of the theta activity. These findings demonstrate, for the first time, objective EEG changes in response to picoTesla range MF in PD. Since the pineal gland is a magnetosensor and as some of the clinical effects produced by MF such as relaxation, sleepiness, mood elevation, increased dreaming, and enhancement of alpha and beta activities in the EEG have also been noted in healthy subjects administered melatonin, we propose that the clinical effects as well as the EEG changes noted after treatment with MF were mediated by the pineal gland which previously has been implicated in the pathophysiology of PD.
我们报告了一名68岁男性，患有帕金森病（PD）7年，多巴胺能和抗胆碱能药物治疗效果甚微。在就诊前的六个月里，他的症状迅速恶化，包括记忆功能下降、抑郁加重以及足部肌张力障碍。皮特斯拉级别的磁场（MF）外用导致震颤和足部肌张力障碍迅速减轻，步态、姿势反射、情绪、焦虑、认知和自主神经功能得到改善。治疗开始三天后，血浆催乳素和促黄体生成素（LH）水平升高。此外，在两次MF治疗九天后记录到明显的脑电图（EEG）变化，包括α和β活动增强以及θ活动消失。这些发现首次证明了PD患者对皮特斯拉级别的MF有客观的EEG变化。由于松果体是一个磁传感器，并且在服用褪黑素的健康受试者中也观察到了MF产生的一些临床效果，如放松、嗜睡、情绪改善、梦境增多以及EEG中α和β活动增强，我们认为MF治疗后观察到的临床效果以及EEG变化是由松果体介导的，而松果体此前已被认为与PD的病理生理学有关。
