Beck M A, Kolbeck P C, Rohr L H, Shi Q, Morris V C, Levander O A
Frank Porter Graham Child Development Center, University of North Carolina, Chapel Hill.
J Med Virol. 1994 Jun;43(2):166-70. doi: 10.1002/jmv.1890430213.
Coxsackieviruses have been implicated as possible co-factors in the etiology of the selenium (Se)-responsive cardiomyopathy known as Keshan disease. Here we report that a cloned and sequenced amyocarditic coxsackievirus B3 (CVB3/0), which causes no pathology in the hearts of Se-adequate mice, induces extensive cardiac pathology in Se-deficient mice. CVB3/0 recovered from the hearts of Se-deficient mice inoculated into Se-adequate mice induced significant heart damage, suggesting mutation of the virus to a virulent genotype. We demonstrate the important role of host nutritional status in determining the severity of a viral infection.
柯萨奇病毒被认为可能是克山病（一种对硒有反应的心肌病）病因中的辅助因素。在此我们报告，一种克隆并测序的无心肌炎柯萨奇病毒B3（CVB3/0），在硒充足的小鼠心脏中不会引起病变，但在缺硒小鼠中会诱发广泛的心脏病变。从接种到硒充足小鼠体内的缺硒小鼠心脏中分离出的CVB3/0会导致显著的心脏损伤，这表明病毒已突变为致病基因型。我们证明了宿主营养状况在决定病毒感染严重程度方面的重要作用。
