作为生物信使的气体：大脑中的一氧化氮和一氧化碳
Gases as biological messengers: nitric oxide and carbon monoxide in the brain.
作者信息
Dawson T M, Snyder S H
机构信息
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
出版信息
J Neurosci. 1994 Sep;14(9):5147-59. doi: 10.1523/JNEUROSCI.14-09-05147.1994.
Abstract
In a remarkably brief period of time, NO and CO have been recognized as putative neurotransmitters. These two novel messenger molecules have greatly expanded the criteria for candidacy of a chemical for the status of neurotransmitter and our notions about how synaptic transmission takes place. The involvement of NO and CO in several important aspects of neuronal function suggests that agents affecting the synthesis, transactions, and disposition of these gases are bound to have clinical relevance.
摘要
在极为短暂的时间内，一氧化氮（NO）和一氧化碳（CO）已被确认为潜在的神经递质。这两种新型信使分子极大地扩展了一种化学物质成为神经递质的候选标准，以及我们对突触传递发生方式的认识。NO和CO参与神经元功能的几个重要方面，这表明影响这些气体合成、传递和处置的药物必然具有临床相关性。
相似文献
1
Gases as biological messengers: nitric oxide and carbon monoxide in the brain.作为生物信使的气体：大脑中的一氧化氮和一氧化碳
J Neurosci. 1994 Sep;14(9):5147-59. doi: 10.1523/JNEUROSCI.14-09-05147.1994.
2
Nitric oxide and carbon monoxide: parallel roles as neural messengers.
Brain Res Brain Res Rev. 1998 May;26(2-3):167-75. doi: 10.1016/s0165-0173(97)00032-5.
3
Carbon Monoxide and Nitric Oxide as Examples of the Youngest Class of Transmitters.一氧化碳和一氧化氮作为新一代递质的范例。
Int J Mol Sci. 2021 Jun 2;22(11):6029. doi: 10.3390/ijms22116029.
4
[Nitric oxide and carbon monoxide--a new generation of neuronal messengers].
Harefuah. 1996 Jun 16;130(12):854-8.
5
Atypical neural messengers.非典型神经信使。
Trends Neurosci. 2001 Feb;24(2):99-106. doi: 10.1016/s0166-2236(00)01716-1.
6
Gaseous second messengers in vertebrate olfaction.
J Neurobiol. 1996 May;30(1):49-57. doi: 10.1002/(SICI)1097-4695(199605)30:1<49::AID-NEU5>3.0.CO;2-G.
7
8
[Nitric oxide and carbon monoxide--a new class of signal molecules].[一氧化氮与一氧化碳——一类新型信号分子]
Usp Fiziol Nauk. 1996 Oct-Dec;27(4):30-43.
9
Gases as chemical messengers in the carotid body. Role of nitric oxide and carbon monoxide in chemoreception.
Adv Exp Med Biol. 1995;393:309-12.
10
Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation.一氧化氮和一氧化碳作为海马体长期增强效应中可能的逆行信使。
J Neurobiol. 1994 Jun;25(6):652-65. doi: 10.1002/neu.480250607.
引用本文的文献
1
Inducible nitric oxide synthase (iNOS): More than an inducible enzyme? Rethinking the classification of NOS isoforms.诱导型一氧化氮合酶（iNOS）：仅仅是一种诱导酶吗？对一氧化氮合酶同工型分类的重新思考。
Pharmacol Res. 2025 Jun;216:107781. doi: 10.1016/j.phrs.2025.107781. Epub 2025 May 17.
2
A Narrative Review of the Expression and Role of Nitric Oxide in Endometriosis.一氧化氮在子宫内膜异位症中的表达及作用的叙述性综述
Antioxidants (Basel). 2025 Feb 20;14(3):247. doi: 10.3390/antiox14030247.
3
Involvement of the GABAergic and the serotonergic systems in the anxiolytic effects expressed by the nitric oxide (NO) donor sodium nitroprusside (SNP) in the male rat.γ-氨基丁酸能和5-羟色胺能系统参与一氧化氮（NO）供体硝普钠（SNP）对雄性大鼠产生的抗焦虑作用。
Psychopharmacology (Berl). 2025 Apr;242(4):793-801. doi: 10.1007/s00213-025-06759-1. Epub 2025 Feb 18.
4
Blocking the Self-Destruct Program of Dopamine Neurons through Macrophage Migration Inhibitory Factor Nuclease Inhibition.通过抑制巨噬细胞迁移抑制因子核酸酶来阻断多巴胺神经元的自毁程序。
Mov Disord. 2024 Apr;39(4):644-650. doi: 10.1002/mds.29748. Epub 2024 Feb 23.
5
Purinoceptors in the Central Nervous System.中枢神经系统中的嘌呤受体。
Drug Dev Res. 1996 Nov-Dec;39(3-4):361-370. doi: 10.1002/(sici)1098-2299(199611/12)39:3/4<361::aid-ddr17>3.0.co;2-4.
6
Are There Lipid Membrane-Domain Subtypes in Neurons with Different Roles in Calcium Signaling?神经元在钙信号转导中具有不同作用，是否存在脂质膜域亚型？
Molecules. 2023 Dec 2;28(23):7909. doi: 10.3390/molecules28237909.
7
CORM-401, an orally active carbon monoxide-releasing molecule, increases body temperature by activating non-shivering thermogenesis in rats.CORM-401是一种口服活性一氧化碳释放分子，通过激活大鼠的非颤抖性产热来升高体温。
Temperature (Austin). 2022 Apr 26;9(4):310-317. doi: 10.1080/23328940.2022.2061270. eCollection 2022.
8
Quantification of cytosol and membrane proteins in rumen epithelium of sheep with low or high CH4 emission phenotype.绵羊低/高 CH4 排放表型瘤胃液蛋白和膜蛋白的定量分析。
PLoS One. 2022 Oct 18;17(10):e0273184. doi: 10.1371/journal.pone.0273184. eCollection 2022.
9
Synaptamide Modulates Astroglial Activity in Mild Traumatic Brain Injury.突触酰胺调节轻度创伤性脑损伤中的星形胶质细胞活性。
Mar Drugs. 2022 Aug 21;20(8):538. doi: 10.3390/md20080538.
10
Devil or angel: two roles of carbon monoxide in stroke.恶魔还是天使：一氧化碳在中风中的双重角色。
Med Gas Res. 2022 Oct-Dec;12(4):125-130. doi: 10.4103/2045-9912.337993.
Zotero 插件