Yamamoto M, Yorioka T, Kawada M, Nishimura K, Kumon Y, Yasuoka N, Suehiro T, Hashimoto K
Second Department of Internal Medicine, Kochi Medical School, Japan.
Nihon Jinzo Gakkai Shi. 1994 Jun;36(6):779-83.
Nephrotic syndrome due to IgA nephropathy was found in a 45-year-old man with psoriasis vulgaris. He was first diagnosed as psoriasis vulgaris at 20 years age and had exhibited proteinuria since 37 years of age. Recently, he developed nephrotic syndrome with unfavorable progression of psoriasis. The conditions of psoriasis and nephrotic syndrome were consistently parallel, and both diseases responded to corticosteroid therapy. The specimens from renal biopsy showed mesangial proliferative glomerulonephritis and sclerosis with mesangial deposition of IgA. Therefore, we diagnosed this case as IgA nephropathy. Twelve cases with chronic glomerulonephritis associated with psoriasis vulgaris have been published. All biopsied specimens from these cases showed mesangial deposition of IgA. Immune abnormalities have been reported in both diseases. The pathogenesis of psoriasis vulgaris and IgA nephropathy may be related through an immune mechanism.
一名患有寻常型银屑病的45岁男性被发现患有IgA肾病所致的肾病综合征。他20岁时首次被诊断为寻常型银屑病，37岁起出现蛋白尿。最近，他发展为肾病综合征，同时银屑病病情进展不佳。银屑病和肾病综合征的病情始终平行，两种疾病对皮质类固醇治疗均有反应。肾活检标本显示系膜增生性肾小球肾炎和硬化，伴有系膜IgA沉积。因此，我们将该病例诊断为IgA肾病。已有12例寻常型银屑病合并慢性肾小球肾炎的病例发表。这些病例的所有活检标本均显示系膜IgA沉积。两种疾病均有免疫异常的报道。寻常型银屑病和IgA肾病的发病机制可能通过免疫机制相关联。
