Evans R W, Orchard T J
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA 15261.
Metabolism. 1994 Sep;43(9):1196-200. doi: 10.1016/0026-0495(94)90065-5.
The increased cardiovascular risk experienced by patients (particularly women) with insulin-dependent diabetes mellitus (IDDM) is not fully explained by conventional risk factors including lipid and lipoprotein concentrations. To determine if plasma lipid peroxide concentrations are relevant to these observations, levels of thiobarbituric acid reactive substances (TBARS) were measured in 56 young adult subjects with IDDM (mean age, 33 years; duration, 24 years) and 56 age- and sex-matched healthy controls. The TBARS concentration was significantly higher in women with diabetes than in female controls (7.4 v 4.5 nmol/mL, P = .001), but not in men with IDDM (5.1 v 5.3 nmol/mL). Diabetic men showed a significant correlation between triglyceride and TBARS concentrations (P < .01), a finding not seen in diabetic women. Furthermore, there was a correlation between glycemic control (hemoglobin A1 [HBA1]) and TBARS in diabetic men, but not in women (P < .01). These findings raise the possibility that the relatively greater increase in cardiovascular disease risk seen in IDDM women compared with men may relate to their increased degree of lipid peroxidation, which is independent of their degree of glycemic control.
胰岛素依赖型糖尿病（IDDM）患者（尤其是女性）心血管疾病风险增加，传统危险因素（包括血脂和脂蛋白浓度）并不能完全解释这一现象。为了确定血浆脂质过氧化物浓度与这些观察结果是否相关，对56名年轻成年IDDM患者（平均年龄33岁；病程24年）和56名年龄及性别匹配的健康对照者进行了硫代巴比妥酸反应性物质（TBARS）水平检测。糖尿病女性的TBARS浓度显著高于女性对照组（7.4对4.5 nmol/mL，P = 0.001），但IDDM男性则无此差异（5.1对5.3 nmol/mL）。糖尿病男性的甘油三酯与TBARS浓度之间存在显著相关性（P < 0.01），而糖尿病女性未观察到这一现象。此外，糖尿病男性的血糖控制（糖化血红蛋白A1 [HBA1]）与TBARS之间存在相关性，而女性则无此相关性（P < 0.01）。这些发现提示，与男性相比，IDDM女性心血管疾病风险相对增加幅度更大，可能与其脂质过氧化程度增加有关，且这一增加与血糖控制程度无关。
