色甘酸钠治疗慢性直肠炎
Disodium cromoglycate in the treatment of chronic proctitis.
作者信息
Heatley R V, Calcraft B J, Rhodes J, Owen E, Evans B K
出版信息
Gut. 1975 Jul;16(7):559-63. doi: 10.1136/gut.16.7.559.
Abstract
The effect of topical disodium cromoglycate (DSCG) has been examined in 30 patients with chronic active proctitis using a double-blind crossover trial. Each treatment period was four weeks and patients were given DSCG 200 mg by enema twice daily and 100 mg orally three times each day. Twenty-six patients completed the trial successfully, 14 responded to DSCG treatment, two improved with placebo, and 10 responded to neither. Patients who responded to DSCG had significantly more eosinophils in their rectal biopsies than those who failed to respond and in some instances the counts were very high. The findings support the hypothesis than an allergic reaction is important in the pathogenesis of proctitis.
摘要
采用双盲交叉试验，对30例慢性活动性直肠炎患者局部应用色甘酸钠（DSCG）的效果进行了研究。每个治疗周期为4周，患者每日接受2次200mg DSCG灌肠治疗，并每日口服3次100mg DSCG。26例患者成功完成试验，14例对DSCG治疗有反应，2例使用安慰剂后病情改善，10例对两者均无反应。对DSCG有反应的患者直肠活检中的嗜酸性粒细胞明显多于无反应者，在某些情况下计数非常高。这些发现支持了过敏反应在直肠炎发病机制中起重要作用的假说。
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