Vaquero J, Morales C, Zurita M, Oya S
Department of Neurosurgery, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Neurosci Lett. 1994 Apr 25;171(1-2):37-40. doi: 10.1016/0304-3940(94)90598-3.
The possible effect of gangliosides as biological modifiers of the ethyl-nitrosourea (ENU) model of neurocarcinogenesis in rats is studied. Wistar rats that were exposed to ENU during fetal life, were treated with gangliosides at a postnatal age corresponding to a stage of pretumor or microtumor development. The results obtained suggest that postnatal administration of gangliosides can influence the development of ENU-induced brain tumors, delaying the appearance of symptomatic neoplasms and improving survival with respect to controls. This finding suggests the potential usefulness of gangliosides in the control of neuroectodermal tumors.
研究了神经节苷脂作为大鼠乙基亚硝基脲（ENU）神经致癌模型生物修饰剂的可能作用。在胎儿期暴露于ENU的Wistar大鼠，在相当于肿瘤前期或微肿瘤发展阶段的出生后年龄接受神经节苷脂治疗。所得结果表明，出生后给予神经节苷脂可影响ENU诱导的脑肿瘤的发展，延迟症状性肿瘤的出现，并提高相对于对照组的存活率。这一发现表明神经节苷脂在控制神经外胚层肿瘤方面具有潜在的用途。
