Boka G, Anglade P, Wallach D, Javoy-Agid F, Agid Y, Hirsch E C
INSERM U289, Hôpital de la Salpêtrière, Paris, France.
Neurosci Lett. 1994 May 19;172(1-2):151-4. doi: 10.1016/0304-3940(94)90684-x.
Activated glial cells observed in the substantia nigra in Parkinson's disease may participate in the mechanism of nerve cell death by providing toxic substances such as cytokines. Among these compounds, tumor necrosis factor-alpha (TNF) is of interest because it can provoke cell death. We detected TNF-immunoreactive glial cells in the substantia nigra of parkinsonian patients but not in those of control subjects. Immunoreactivity for TNF receptors was found in cell bodies and processes of most dopaminergic neurons of control and parkinsonian subjects, suggesting that nigral dopaminergic neurons might be sensitive to TNF produced in Parkinson's disease. These results suggest that TNF may participate in the degenerative processes occurring in Parkinson's disease, at least after a primary insult inducing a reactive gliosis.
在帕金森病患者黑质中观察到的活化胶质细胞可能通过提供细胞因子等有毒物质参与神经细胞死亡机制。在这些化合物中，肿瘤坏死因子-α（TNF）备受关注，因为它可引发细胞死亡。我们在帕金森病患者的黑质中检测到了TNF免疫反应性胶质细胞，而在对照受试者中未检测到。在对照和帕金森病受试者的大多数多巴胺能神经元的细胞体和突起中发现了TNF受体的免疫反应性，这表明黑质多巴胺能神经元可能对帕金森病中产生的TNF敏感。这些结果表明，TNF可能参与帕金森病中发生的退行性过程，至少在引发反应性胶质增生的原发性损伤之后是如此。
