Monteleone P, Catapano F, Del Buono G, Maj M
Institute of Psychiatry, First Medical School, University of Naples, Italy.
Acta Psychiatr Scand. 1994 Jun;89(6):411-5. doi: 10.1111/j.1600-0447.1994.tb01538.x.
Plasma melatonin, cortisol and prolactin (PRL) levels were measured over a 24-h period in 13 drug-free patients with obsessive-compulsive disorder and in matched healthy subjects. The circadian profiles of melatonin and PRL were altered in patients; the circadian rhythm of cortisol was preserved, although at a higher level compared with normal controls. These changes were significantly related to the severity of the obsessive-compulsive symptoms. Further studies need to clarify the state- or trait-dependent character of these abnormalities.
在24小时内，对13名未服用药物的强迫症患者以及匹配的健康受试者测量了血浆褪黑素、皮质醇和催乳素（PRL）水平。患者的褪黑素和PRL昼夜节律发生了改变；皮质醇的昼夜节律得以保留，尽管与正常对照组相比处于较高水平。这些变化与强迫症症状的严重程度显著相关。进一步的研究需要阐明这些异常是状态依赖性还是特质依赖性。
