尿黑酸是MelA的产物，MelA在海洋细菌考氏希瓦氏菌D中介导黑色素生成。
Homogentisic acid is the product of MelA, which mediates melanogenesis in the marine bacterium Shewanella colwelliana D.
作者信息
Coon S L, Kotob S, Jarvis B B, Wang S, Fuqua W C, Weiner R M
机构信息
Department of Microbiology, University of Maryland, College Park 20742.
出版信息
Appl Environ Microbiol. 1994 Aug;60(8):3006-10. doi: 10.1128/aem.60.8.3006-3010.1994.
Abstract
Shewanella colwelliana D is a marine procaryote which produces a diffusible brown pigment that correlates with melA gene expression. Previously, melA had been cloned, sequenced, and expressed in Escherichia coli; however, the reaction product of MelA had not been identified. This report identifies that product as homogentisic acid, provides evidence that the pigment is homogentisic acid-melanin (pyomelanin), and suggests that MelA is p-hydroxyphenylpyruvate hydroxylase. This is the first report of pyomelanin in an obligate marine bacterium.
摘要
科尔韦尔希瓦氏菌D是一种海洋原核生物，它能产生一种与melA基因表达相关的可扩散棕色色素。此前，melA已被克隆、测序并在大肠杆菌中表达；然而，MelA的反应产物尚未被鉴定。本报告鉴定该产物为尿黑酸，提供了该色素是尿黑酸-黑色素（脓黑素）的证据，并表明MelA是对羟基苯丙酮酸羟化酶。这是关于专性海洋细菌中脓黑素的首次报道。
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