Samarina I V, Taran I F, Proskurina V A
Antibiot Khimioter. 1993 Dec;38(12):18-20.
The character of drug interaction in 18 various combinations of sisomicin, amikacin, gentamicin, cefotaxime, doxycycline, trimethoprim and nitroxaline was studied by the chess board method with respect to 25 strains of Brucella melitensis. The synergistic effect with respect to the majority of the cultures was observed with the use of the combinations of gentamicin, amikacin or sisomicin with doxycycline. The combinations of the aminoglycosides with cefotaxime and sisomicin or gentamicin with rifampicin had a summation effect on the majority of the cultures. With the use of the combinations of cefotaxime with nitroxaline or trimethoprim and rifampicin with nitroxaline the effect on the majority of the cultures was indifferent. The effect was mainly antagonistic with the use of the combinations of amikacin with rifampicin, gentamicin with trimethoprim and cefotaxime with doxycycline. The effect of the combinations of gentamicin with nitroxaline and cefotaxime with rifampicin was different with respect to different strains of B. melitensis. It was indifferent, antagonistic or summation depending on the strain.
采用棋盘法，针对25株羊种布鲁氏菌，研究了西索米星、阿米卡星、庆大霉素、头孢噻肟、多西环素、甲氧苄啶和硝咯喹啉18种不同组合的药物相互作用特点。使用庆大霉素、阿米卡星或西索米星与多西环素的组合时，对大多数培养物观察到协同作用。氨基糖苷类与头孢噻肟以及西索米星与利福平的组合对大多数培养物具有相加作用。使用头孢噻肟与硝咯喹啉或甲氧苄啶以及利福平与硝咯喹啉的组合时，对大多数培养物的作用无明显差异。使用阿米卡星与利福平、庆大霉素与甲氧苄啶以及头孢噻肟与多西环素的组合时，作用主要为拮抗。庆大霉素与硝咯喹啉以及头孢噻肟与利福平的组合对不同羊种布鲁氏菌菌株的作用不同，根据菌株不同可为无明显差异、拮抗或相加。
