Balint G A, Varró V
Agents Actions. 1985 Oct;17(1):46-7. doi: 10.1007/BF01966680.
Using a specific radioimmunoassay technique it seems that Prostacyclin (PG-I2) has a strong effect on the cyclic nucleotide content of the rat gastric (fundic) mucosa. 1 min after an intragastric application of 100 micrograms/kg PG-I2 the cAMP-content and in the 5th min the cGMP-content showed a highly significant decrease. It seems that the basic mechanism of action of PG-I2 is a typical 'hit and run' effect, acting on the intracellular 'second messenger system'.
使用一种特定的放射免疫分析技术，前列环素（PG-I2）似乎对大鼠胃（胃底）黏膜的环核苷酸含量有强烈影响。胃内给予100微克/千克PG-I2后1分钟，cAMP含量以及在第5分钟时cGMP含量均呈现高度显著下降。PG-I2的基本作用机制似乎是一种典型的“打了就跑”效应，作用于细胞内的“第二信使系统”。
