Whipp B J
Department of Physiology, St. George's Hospital Medical School, London, United Kingdom.
Clin Chest Med. 1994 Jun;15(2):173-92.
Exercise intolerance results when a subject is unable to sustain a required work rate sufficiently long for the successful completion of the task. The ability to sustain muscular exercise depends in large part on the ability to transport oxygen to its site of utilization as the terminal oxidant of the mitochondrial electron transport chain. This requires a coordinated interaction of skeletal muscle energetics and cardiovascular and pulmonary responses to the task. This article considers the fundamentals of the normal operation of these systems and their patterns of response to particular stress profiles to provide a frame of reference for the normalcy of responses to exercise testing.
当受试者无法维持所需的工作强度足够长的时间以成功完成任务时，就会出现运动不耐受。维持肌肉运动的能力在很大程度上取决于将氧气输送到其作为线粒体电子传递链末端氧化剂的利用部位的能力。这需要骨骼肌能量学与心血管和肺部对任务的反应之间进行协调互动。本文探讨了这些系统正常运作的基本原理及其对特定应激模式的反应模式，为运动测试反应的正常性提供一个参考框架。
