Tu L H, Huang D R, Zhang R Q, Shen Q, Yu Y Y, Hong Y F, Li G H
Changhai Hospital, Second Military Medical University, Shanghai.
Chin Med J (Engl). 1994 Apr;107(4):300-3.
With overall analysis of symptoms and signs of myasthenia gravis (MG) basing on "Pi (Spleen) Deficiency" [symbol: see text] theory and with years of our clinical experience in treating MG, we performed a pharmacological study of Astragalus saponins and Buzhong Yiqi Compound (Tonic granulae invigorating vital energy) in 14 peripheral blood mononuclear cell (PBMNC) cultures from 10 MG patients. PBMNG from two groups of patients given dexamethasone (Dxm) and cobalt 60 (60Co) treatment were used as controls. The results showed that water soluble Astragalus saponins significantly reduced the titer of nicotinic acetylcholine receptor antibodies (nAchR-Ab) in the cell culture supernatants, from 418.8-2328 to nil in 6 cases, and from 1143-1235 to 43-157 fmol/ml in 2 cases, and that Buzhong Yiqi compound also had inhibitory immunoregulatory action.
基于“脾虚”理论对重症肌无力（MG）的症状和体征进行综合分析，并结合我们多年治疗MG的临床经验，我们对10例MG患者的14份外周血单个核细胞（PBMNC）培养物进行了黄芪皂苷和补中益气复方（补气颗粒）的药理学研究。给予地塞米松（Dxm）和钴60（60Co）治疗的两组患者的PBMNG用作对照。结果表明，水溶性黄芪皂苷显著降低了细胞培养上清液中烟碱型乙酰胆碱受体抗体（nAchR-Ab）的滴度，6例患者从418.8 - 2328降至零，2例患者从1143 - 1235降至43 - 157 fmol/ml，并且补中益气复方也具有免疫调节抑制作用。
