Eggert-Kruse W, Kruse W, Rohr G, Müller S, Kreissler-Haag D, Klinga K, Runnebaum B
Abteilung für Gynäkologische Endokrinologie und Fertilitätsstörungen, Universitäts-Frauenklinik Heidelberg.
Geburtshilfe Frauenheilkd. 1994 Jun;54(6):321-31. doi: 10.1055/s-2007-1022849.
In 136 women with a median age of 78 (60-98) years the serum concentrations of FSH, LH, prolactin, estradiol-17 beta, testosterone and DHEA-S were determined completed by GnRH and ACTH stimulation tests in a subgroup. This resulted in median values for FSH of 15.8 ng/ml, LH 6.4 ng/ml, prolactin 6.9 ng/ml, estradiol 16 pg/ml, testosterone 270 pg/ml and 306 ng/ml for DHEA-S. No correlation with age in this population was found for gonadotropins as well as the other hormones for an age level of up to 98 years. Determination of multiple general clinical and laboratory parameters demonstrate the significance particularly in a geriatric group of patients to consider these patient characteristics when interpreting the serum hormone levels. In summary, the results of this prospective study underline the importance for health, of the secretion of gonadotropic and sexual hormones even at a very advanced age.
在136名中位年龄为78岁（60 - 98岁）的女性中，测定了促卵泡激素（FSH）、促黄体生成素（LH）、催乳素、雌二醇 - 17β、睾酮和硫酸脱氢表雄酮（DHEA - S）的血清浓度，并对其中一个亚组进行了促性腺激素释放激素（GnRH）和促肾上腺皮质激素（ACTH）刺激试验。结果显示，FSH的中位值为15.8 ng/ml，LH为6.4 ng/ml，催乳素为6.9 ng/ml，雌二醇为16 pg/ml，睾酮为270 pg/ml，DHEA - S为306 ng/ml。在该人群中，年龄高达98岁时，促性腺激素以及其他激素与年龄均无相关性。多项一般临床和实验室参数的测定表明，在老年患者群体中，解释血清激素水平时考虑这些患者特征尤为重要。总之，这项前瞻性研究的结果强调了即使在高龄时促性腺激素和性激素分泌对健康的重要性。
