• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Isolation and characterization of paramecium mutants defective in their response to magnesium.对镁反应存在缺陷的草履虫突变体的分离与鉴定
Genetics. 1994 Jul;137(3):759-69. doi: 10.1093/genetics/137.3.759.
2
Inhibition of Mg2+ current by single-gene mutation in Paramecium.草履虫单基因突变对镁离子电流的抑制作用。
J Membr Biol. 1994 May;139(3):203-13. doi: 10.1007/BF00232624.
3
A Novel Role for Polycystin-2 (Pkd2) in as a Probable Mg Channel Necessary for Mg-Induced Behavior.多囊蛋白-2（Pkd2）在中作为可能的镁通道的新作用，对于镁诱导的行为是必需的。
Genes (Basel). 2019 Jun 14;10(6):455. doi: 10.3390/genes10060455.
4
Phenotypic and genetic analysis of "Chameleon," a paramecium mutant with an enhanced sensitivity to magnesium.对“变色龙”（一种对镁敏感性增强的草履虫突变体）的表型和遗传分析。
Genetics. 1997 Jul;146(3):871-80. doi: 10.1093/genetics/146.3.871.
5
An exchanger-like protein underlies the large Mg2+ current in Paramecium.一种类似交换器的蛋白质是草履虫中大量镁离子电流的基础。
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15717-22. doi: 10.1073/pnas.242603999. Epub 2002 Nov 6.
6
Extracellular GTP causes membrane-potential oscillations through the parallel activation of Mg2+ and Na+ currents in Paramecium tetraurelia.细胞外鸟苷三磷酸（GTP）通过平行激活四膜虫中的镁离子（Mg2+）和钠离子（Na+）电流，引起膜电位振荡。
J Membr Biol. 1997 May 15;157(2):159-67. doi: 10.1007/s002329900225.
7
New mutants of Paramecium tetraurelia defective in a calcium control mechanism: genetic and behavioral characterizations.四膜虫钙调控机制缺陷的新突变体：遗传与行为特征分析
Genetics. 1989 Mar;121(3):491-500. doi: 10.1093/genetics/121.3.491.
8
Correlation between loss of a Mg2+ conductance and an adaptation defect in a mutant of Paramecium tetraurelia.四膜虫突变体中镁离子电导丧失与适应缺陷之间的相关性。
J Eukaryot Microbiol. 1999 May-Jun;46(3):290-7. doi: 10.1111/j.1550-7408.1999.tb05127.x.
9
Molecular and genetic analyses of the B type surface protein gene from Paramecium tetraurelia.四膜虫B型表面蛋白基因的分子与遗传分析
Genetics. 1993 May;134(1):189-98. doi: 10.1093/genetics/134.1.189.
10
The molecular basis for the alternative stable phenotype in a behavioral mutant of Paramecium tetraurelia.四膜虫行为突变体中交替稳定表型的分子基础。
Genes Genet Syst. 2001 Oct;76(5):289-94. doi: 10.1266/ggs.76.289.

引用本文的文献

1
, a Model to Study Ciliary Beating and Ciliogenesis: Insights From Cutting-Edge Approaches.一种研究纤毛摆动和纤毛发生的模型：前沿方法的见解
Front Cell Dev Biol. 2022 Mar 14;10:847908. doi: 10.3389/fcell.2022.847908. eCollection 2022.
2
Using as a Model for Ciliopathies.以 为例研究纤毛病。
Genes (Basel). 2021 Sep 24;12(10):1493. doi: 10.3390/genes12101493.
3
A Novel Role for Polycystin-2 (Pkd2) in as a Probable Mg Channel Necessary for Mg-Induced Behavior.多囊蛋白-2（Pkd2）在中作为可能的镁通道的新作用，对于镁诱导的行为是必需的。
Genes (Basel). 2019 Jun 14;10(6):455. doi: 10.3390/genes10060455.
4
Novel Insights into the Development and Function of Cilia Using the Advantages of the Paramecium Cell and Its Many Cilia.利用草履虫细胞及其众多纤毛的优势对纤毛的发育和功能的新见解。
Cells. 2015 Jul 29;4(3):297-314. doi: 10.3390/cells4030297.
5
Ion channels in microbes.微生物中的离子通道。
Physiol Rev. 2008 Oct;88(4):1449-90. doi: 10.1152/physrev.00005.2008.
6
An exchanger-like protein underlies the large Mg2+ current in Paramecium.一种类似交换器的蛋白质是草履虫中大量镁离子电流的基础。
Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15717-22. doi: 10.1073/pnas.242603999. Epub 2002 Nov 6.
7
Isolation and characterization of magbane, a magnesium-lethal mutant of paramecium.草履虫镁致死突变体玛格班的分离与鉴定
Genetics. 2001 Jul;158(3):1061-9. doi: 10.1093/genetics/158.3.1061.
8
Oscillating response to a purine nucleotide disrupted by mutation in Paramecium tetraurelia.四膜虫中的突变破坏了对嘌呤核苷酸的振荡反应。
Biochem J. 1998 Feb 15;330 ( Pt 1)(Pt 1):139-47. doi: 10.1042/bj3300139.
9
Lysozyme acts as a chemorepellent and secretagogue in Paramecium by activating a novel receptor-operated Ca++ conductance.溶菌酶通过激活一种新型的受体操纵性钙离子通道，在草履虫中充当化学排斥剂和促分泌素。
J Membr Biol. 1995 Nov;148(1):13-25. doi: 10.1007/BF00234152.

本文引用的文献

1
K-resistant mutants and "adaptation" in Paramecium.草履虫中的抗K突变体与“适应性”
Proc Natl Acad Sci U S A. 1978 Nov;75(11):5645-9. doi: 10.1073/pnas.75.11.5645.
2
Control of exocytotic processes: cytological and physiological studies of trichocyst mutants in Paramecium tetraurelia.胞吐过程的调控：四膜虫中刺丝泡突变体的细胞学与生理学研究
J Cell Biol. 1981 Feb;88(2):301-11. doi: 10.1083/jcb.88.2.301.
3
Mutant analysis shows that the Ca2+-induced K+ current shuts off one type of excitation in Paramecium.突变分析表明，钙离子诱导的钾电流关闭了草履虫中的一种兴奋类型。
Proc Natl Acad Sci U S A. 1983 Aug;80(16):5112-6. doi: 10.1073/pnas.80.16.5112.
4
Membrane currents of pawn mutants of the pwA group in Paramecium tetraurelia.四膜虫pwA组pawn突变体的膜电流
J Exp Biol. 1980 Feb;84:57-71. doi: 10.1242/jeb.84.1.57.
5
A mutation that alters properties of the calcium channel in Paramecium tetraurelia.一种改变四膜虫钙通道特性的突变。
J Physiol. 1984 Jun;351:397-410. doi: 10.1113/jphysiol.1984.sp015252.
6
Genic mutants with altered system of excitation in Paramecium aurelia. II. Mutagenesis, screening and genetic analysis of the mutants.尾草履虫中具有改变的兴奋系统的基因变异体。II. 变异体的诱变、筛选及遗传分析
Genetics. 1971 Sep;69(1):29-45. doi: 10.1093/genetics/69.1.29.
7
Membrane excitability: made temperature-dependent by mutations.膜兴奋性：因突变而受温度影响。
Proc Natl Acad Sci U S A. 1974 Jul;71(7):2703-6. doi: 10.1073/pnas.71.7.2703.
8
Magnesium as a regulatory cation: criteria and evaluation.镁作为一种调节性阳离子：标准与评估
Magnesium. 1987;6(3):113-27.
9
New mutants of Paramecium tetraurelia defective in a calcium control mechanism: genetic and behavioral characterizations.四膜虫钙调控机制缺陷的新突变体：遗传与行为特征分析
Genetics. 1989 Mar;121(3):491-500. doi: 10.1093/genetics/121.3.491.
10
Magnesium ions in cardiac function. Regulator of ion channels and second messengers.镁离子在心脏功能中的作用。离子通道和第二信使的调节因子。
Biochem Pharmacol. 1989 Mar 15;38(6):859-67. doi: 10.1016/0006-2952(89)90272-4.

对镁反应存在缺陷的草履虫突变体的分离与鉴定

Isolation and characterization of paramecium mutants defective in their response to magnesium.

作者信息

Preston R R, Kung C

机构信息

Laboratory of Molecular Biology, University of Wisconsin-Madison 53706.

出版信息

Genetics. 1994 Jul;137(3):759-69. doi: 10.1093/genetics/137.3.759.

DOI:10.1093/genetics/137.3.759
PMID:8088522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1206036/
Abstract

Four mutant strains of Paramecium tetraurelia with a reduced ability to respond behaviorally to Mg2+ have been isolated. Voltage-clamp analyses showed that their Mg2+ insensitivity is associated with a reduced Ca(2+)-dependent Mg2+ current. The four mutants, which have been doubled "eccentric," result from recessive mutations in two unlinked loci, xntA and xntB. Further analysis of xntA1 showed it to be unlinked to any of the behavioral mutants of P. tetraurelia described previously, but it is allelic to d4-521, a "K(+)-resistant" strain, and d4-596, a "Ba(2+)-shy" mutant. The varied pleiotropic effects of xntA1, which include increased resistance to Ni2+ and Zn2+ poisoning, suggest that the locus encodes a central regulator of cell function in Paramecium.

摘要

已分离出四株对Mg2+行为反应能力降低的四膜虫突变株。电压钳分析表明，它们对Mg2+的不敏感性与Ca(2+)依赖性Mg2+电流的降低有关。这四个已加倍的“偏心”突变体是由两个不连锁基因座xntA和xntB中的隐性突变产生的。对xntA1的进一步分析表明，它与先前描述的四膜虫的任何行为突变体都不连锁，但它与“抗K(+)”菌株d4-521和“怕Ba(2+)”突变体d4-596等位。xntA1具有多种多效性效应，包括对Ni2+和Zn2+中毒的抗性增加，这表明该基因座编码四膜虫细胞功能的中央调节因子。