Rodeheaver G T, Pettry D, Thacker J G, Edgerton M T, Edlich R F
Surg Gynecol Obstet. 1975 Sep;141(3):357-62.
All traumatic wounds are contaminated to some degree by both soil and bacteria. Specific infection potentiating factors in soil impair the defenses of the tissue and invite infection. These factors are small in size and resist removal by low pressure irrigation. The efficiency of wound irrigation is markedly improved by delivering the irrigant to the wound under continuous high pressure. Irrigation of the wound with saline solution delivered at 15 pounds per square inch removed 84.8 per cent of the soil infection potentiating factors from the wound. The residual infection potentiating factors remaining in the wound did not significantly impair tissue defenses. On the basis of these experimental studies, clinical studies are now being initiated to test the therapeutic value of high pressure irrigation in traumatic wounds in humans.
所有创伤性伤口在某种程度上都会被土壤和细菌污染。土壤中的特定感染增强因素会损害组织的防御能力并引发感染。这些因素体积小，低压冲洗无法将其清除。通过在持续高压下将冲洗液输送到伤口，伤口冲洗的效率会显著提高。以每平方英寸15磅的压力输送盐溶液冲洗伤口，可去除伤口中84.8%的土壤感染增强因素。伤口中残留的感染增强因素并未显著损害组织防御能力。基于这些实验研究，目前正在开展临床研究，以测试高压冲洗对人类创伤性伤口的治疗价值。
