Laguna F, López-Vélez R, Soriano V, Montilla P, Alvar J, González-Lahoz J M
Instituto de Salud Carlos III, Madrid, Spain.
J Infect. 1994 May;28(3):255-9. doi: 10.1016/s0163-4453(94)91643-8.
We report on 11 patients with HIV infection and visceral leishmaniasis and who were treated with meglumine antimoniate plus allopurinol for 3 weeks (six patients) or 4 weeks (five patients). Clinical and parasitological cures were achieved in four of the five patients treated for 4 weeks and in one of the six patients treated for 3 weeks. Only one patient developed a severe maculopapular rash. Allopurinol plus meglumine antimoniate was found to be a safe combination of drugs for the treatment of visceral leishmaniasis in patients infected with HIV. The optimal length of this treatment is unknown but a course of at least 4 weeks' duration would appear to be necessary for obtaining parasitological cure in most cases.
我们报告了11例感染HIV且患有内脏利什曼病的患者，他们接受了葡甲胺锑酸盐加别嘌醇治疗，疗程为3周（6例患者）或4周（5例患者）。接受4周治疗的5例患者中有4例实现了临床和寄生虫学治愈，接受3周治疗的6例患者中有1例实现了临床和寄生虫学治愈。仅1例患者出现严重的斑丘疹。发现别嘌醇加葡甲胺锑酸盐是治疗HIV感染患者内脏利什曼病的一种安全药物组合。这种治疗的最佳疗程尚不清楚，但在大多数情况下，似乎需要至少4周的疗程才能实现寄生虫学治愈。
