局灶性坏死性单纯疱疹性脑炎：两例临床及神经心理学预后良好的病例报告

Counsell C E, Taylor R, Whittle I R

Department of Clinical Neurosciences, Western General Hospital, Edinburgh, UK.

J Neurol Neurosurg Psychiatry. 1994 Sep;57(9):1115-7. doi: 10.1136/jnnp.57.9.1115.

Two patients with atypical focal necrotising herpes simplex encephalitis are described. They presented with relatively mild clinical disease but despite treatment with acyclovir (10 mg/kg/day for three days in case 1 and 10 days in case 2) they developed dramatic, progressive changes (shown on brain CT) that mimicked space occupying lesions of the temporal lobes. Both patients therefore had a diagnostic and therapeutic temporal lesionectomy followed by further 10 day courses of acyclovir. They subsequently went on to make good clinical and neuropsychological recoveries.

本文描述了两名非典型局灶性坏死性单纯疱疹性脑炎患者。他们临床表现相对较轻，但尽管接受了阿昔洛韦治疗（病例1为10mg/kg/天，持续三天；病例2为10天），仍出现了显著的、进行性的变化（脑部CT显示），类似于颞叶占位性病变。因此，两名患者均接受了诊断性和治疗性颞叶病灶切除术，随后又进行了为期10天的阿昔洛韦治疗。他们随后在临床和神经心理学方面都恢复良好。