Pan D A, Hulbert A J, Storlien L H
Department of Medicine (Endocrinology), University of Sydney, NSW Australia.
J Nutr. 1994 Sep;124(9):1555-65. doi: 10.1093/jn/124.9.1555.
Modifications in dietary fat profile have been shown to affect body weight gain and adiposity. This may occur through changes in the partitioning between oxidation and storage and/or alterations in membrane structure, which may in turn influence metabolic rate. All the dietary fat classes are substrates for the biosynthetic elongase and desaturase enzymes. Obesity is associated with increased delta 9 desaturase activity, reduced delta 5 desaturase activity and perhaps reduced delta 6 desaturase activity. Dietary lipid profile can affect the activity of each of these enzymes. A number of possible mechanisms linking dietary fat subtypes with development of obesity are discussed, including modification of sodium potassium pump activity and alterations in mitochondrial proton leakage.
饮食脂肪构成的改变已被证明会影响体重增加和肥胖程度。这可能是通过氧化与储存之间分配的变化和/或膜结构的改变而发生的，而这反过来可能会影响代谢率。所有膳食脂肪类别都是生物合成延长酶和去饱和酶的底物。肥胖与Δ9去饱和酶活性增加、Δ5去饱和酶活性降低以及可能的Δ6去饱和酶活性降低有关。饮食脂质构成会影响这些酶中每一种的活性。本文讨论了将膳食脂肪亚型与肥胖发展联系起来的一些可能机制，包括钠钾泵活性的改变和线粒体质子泄漏的变化。
